Background AKT, also known as protein kinase B, is a key element of the PI3K/AKT
signaling pathway. Moreover, AKT regulates the hallmarks of cancer, eg tumor growth …

Fibroblast growth factor receptor (FGFR) signaling is involved in multiple biological
processes, including cell proliferation, survival, differentiation, migration, and apoptosis …

Abstract Development of candidate cancer treatments is a resource-intensive process, with
the research community continuing to investigate options beyond static genomic …

The human genome encodes thousands of long noncoding RNA (lncRNA) genes; the
function of majority of them is poorly understood. Aberrant expression of a significant …

Purpose: Our objective was to identify the genetic changes involved in primary central
nervous system lymphoma (PCNSL) oncogenesis and evaluate their clinical relevance …

NUT midline carcinoma (NMC), a subtype of squamous cell cancer, is one of the most
aggressive human solid malignancies known. NMC is driven by the creation of a …

Breast cancer in young women is more aggressive with a poorer prognosis and overall
survival compared to older women diagnosed with the disease. Despite recent research, the …

PIK3CA, which codes for the p110α catalytic subunit of phosphatidylinositol 3-kinase, is one
of the most frequently mutated genes in human breast cancer. Here, we describe a mouse …

To gain insight into the role of genomic alterations in breast cancer progression, we
conducted a comprehensive genetic characterization of a series of four cell lines derived …

Ovarian cancer is a disease characterised by complex genomic rearrangements but the
majority of the genes that are the target of these alterations remain unidentified. Cataloguing …