The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …

Metabolic alterations are a key hallmark of cancer cells, and the augmented synthesis and
use of nucleotide triphosphates is a critical and universal metabolic dependency of cancer …

Lipid nanoparticle (LNP)-formulated messenger RNA (mRNA) vaccineare a promising
platform to prevent infectious diseases as demonstrated by the recent success of SARS-CoV …

As mRNA vaccines have proved to be very successful in battling the coronavirus disease
2019 (COVID-19) pandemic, this new modality has attracted widespread interest for the …

Many of the ligands for Toll-like receptors (TLRs) are unique to microorganisms, such that
receptor activation unequivocally indicates the presence of something foreign. However, a …

The study of innate immunity and its link to inflammation and host defense encompasses
diverse areas of biology, ranging from genetics and biophysics to signal transduction and …

Vaccines are critical tools for maintaining global health. Traditional vaccine technologies
have been used across a wide range of bacterial and viral pathogens, yet there are a …

Abstract mRNA vaccines represent a promising alternative to conventional vaccine
approaches because of their high potency, capacity for rapid development and potential for …

UNC93B1 is critical for trafficking and function of nucleic acid–sensing Toll-like receptors
(TLRs) TLR3, TLR7, TLR8, and TLR9, which are essential for antiviral immunity. Overactive …

During the COVID-19 pandemic, mRNA (mRNA) vaccines emerged as leading vaccine
candidates in a record time. Nonreplicating mRNA (NRM) and self-amplifying mRNA (SAM) …