The emergence and evolution of SARS-CoV-2

EC Holmes - Annual review of virology, 2024 - annualreviews.org
The origin of SARS-CoV-2 has evoked heated debate and strong accusations, yet
seemingly little resolution. I review the scientific evidence on the origin of SARS-CoV-2 and …

SARS-CoV-2 evolution from the BA. 2.86 to JN. 1 variants: unexpected consequences

X Wang, L Lu, S Jiang - Trends in Immunology, 2024 - cell.com
SARS-CoV-2 is continuously evolving. The Omicron subvariant BA. 2.86, with> 30 mutations
in its spike (S) protein compared with its predecessor strain BA. 2, was expected to quickly …

Fast evolution of SARS-CoV-2 BA. 2.86 to JN. 1 under heavy immune pressure

S Yang, Y Yu, Y Xu, F Jian, W Song… - The Lancet Infectious …, 2024 - thelancet.com
The SARS-CoV-2 saltation variant BA. 2.86, which was quickly designated as a variant
under monitoring after its emergence, has garnered global attention. Although BA. 2.86 did …

Evolution and neutralization escape of the SARS-CoV-2 BA. 2.86 subvariant

K Khan, G Lustig, C Römer, K Reedoy, Z Jule… - Nature …, 2023 - nature.com
Abstract Omicron BA. 2.86 subvariant differs from Omicron BA. 2 as well as recently
circulating variants by over 30 mutations in the spike protein alone. Here we report on the …

Distinct evolution of SARS-CoV-2 Omicron XBB and BA. 2.86/JN. 1 lineages combining increased fitness and antibody evasion

D Planas, I Staropoli, V Michel, F Lemoine… - Nature …, 2024 - nature.com
The unceasing circulation of SARS-CoV-2 leads to the continuous emergence of novel viral
sublineages. Here, we isolate and characterize XBB. 1, XBB. 1.5, XBB. 1.9. 1, XBB. 1.16. 1 …

Virological characteristics of the SARS-CoV-2 JN. 1 variant

Y Kaku, K Okumura, M Padilla-Blanco… - The Lancet Infectious …, 2024 - thelancet.com
4 Yang S, Yu Y, Jian F, et al. Antigenicity and infectivity characterisation of SARS-CoV-2 BA.
2.86. Lancet Infect Dis 2023; 23: e457–59. 5 Kosugi Y, Plianchaisuk A, Putri O, et al …

Spike deep mutational scanning helps predict success of SARS-CoV-2 clades

B Dadonaite, J Brown, TE McMahon, AG Farrell… - Nature, 2024 - nature.com
SARS-CoV-2 variants acquire mutations in the spike protein that promote immune evasion
and affect other properties that contribute to viral fitness, such as ACE2 receptor binding and …

[HTML][HTML] Humoral immune escape by current SARS-CoV-2 variants BA. 2.86 and JN. 1, December 2023

LM Jeworowski, B Mühlemann, F Walper… - …, 2024 - eurosurveillance.org
Variant BA. 2.86 and its descendant, JN. 1, of SARS-CoV-2 are rising in incidence across
Europe and globally. We isolated recent JN. 1, BA. 2.86, EG. 5, XBB. 1.5 and earlier variants …

[HTML][HTML] Virological characteristics of the SARS-CoV-2 BA. 2.86 variant

T Tamura, K Mizuma, H Nasser, S Deguchi… - Cell Host & Microbe, 2024 - cell.com
In late 2023, several SARS-CoV-2 XBB descendants, notably EG. 5.1, were predominant
worldwide. However, a distinct SARS-CoV-2 lineage, the BA. 2.86 variant, also emerged …

XBB. 1.5 monovalent mRNA vaccine booster elicits robust neutralizing antibodies against XBB subvariants and JN. 1

Q Wang, Y Guo, A Bowen, IA Mellis, R Valdez… - Cell host & …, 2024 - cell.com
COVID-19 vaccines have recently been updated to specifically encode or contain the spike
protein of the SARS-CoV-2 XBB. 1.5 subvariant, but their immunogenicity in humans has yet …