Exosomes─ nature's lipid nanoparticles, a rising star in drug delivery and diagnostics

R Tenchov, JM Sasso, X Wang, WS Liaw, CA Chen… - ACS …, 2022 - ACS Publications
Exosomes are a subgroup of nanosized extracellular vesicles enclosed by a lipid bilayer
membrane and secreted by most eukaryotic cells. They represent a route of intercellular …

Recent advances in exosome-mediated nucleic acid delivery for cancer therapy

Y Zhang, Q Liu, X Zhang, H Huang, S Tang… - Journal of …, 2022 - Springer
Cancer is a leading public health problem worldwide. Its treatment remains a daunting
challenge, although significant progress has been made in existing treatments in recent …

Molecular biomarkers in cancer

VK Sarhadi, G Armengol - Biomolecules, 2022 - mdpi.com
Molecular cancer biomarkers are any measurable molecular indicator of risk of cancer,
occurrence of cancer, or patient outcome. They may include germline or somatic genetic …

Autophagy and cancer drug resistance in dialogue: pre-clinical and clinical evidence

Y Qin, M Ashrafizadeh, V Mongiardini, B Grimaldi… - Cancer letters, 2023 - Elsevier
The emergence of drug resistance is a major challenge for oncologists. Resistance can be
categorized as acquired or intrinsic; the alteration of several biological mechanisms …

Extracellular vesicles and particles impact the systemic landscape of cancer

S Lucotti, CM Kenific, H Zhang, D Lyden - The EMBO journal, 2022 - embopress.org
Intercellular cross talk between cancer cells and stromal and immune cells is essential for
tumor progression and metastasis. Extracellular vesicles and particles (EVPs) are a …

Liquid biopsy: Exosomal microRNAs as novel diagnostic and prognostic biomarkers in cancer

KA Preethi, SC Selvakumar, K Ross, S Jayaraman… - Molecular Cancer, 2022 - Springer
Background Detecting cancer at an early stage before clinical manifestation could be an
effective strategy to decrease cancer mortality. Thus, identifying liquid biopsy biomarkers …

Beclin1-mediated interplay between autophagy and apoptosis: New understanding

K Prerna, VK Dubey - International journal of biological macromolecules, 2022 - Elsevier
The definition for autophagy holds a 'single'meaning as a conserved cellular process that
constitutes a recycling pathway for damaged organelles and long-lived proteins to maintain …

Mesenchymal stem cell-derived exosomes loaded with miR-155 inhibitor ameliorate diabetic wound healing

P Gondaliya, AA Sayyed, P Bhat, M Mali… - Molecular …, 2022 - ACS Publications
Diabetic wounds are one of the debilitating complications that affect up to 20% of diabetic
patients. Despite the advent of extensive therapies, the recovery rate is unsatisfactory, and …

[HTML][HTML] Exosomes, autophagy and ER stress pathways in human diseases: Cross-regulation and therapeutic approaches

B Jahangiri, AK Saei, PO Obi, N Asghari… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Exosomal release pathway and autophagy together maintain homeostasis and survival of
cells under stressful conditions. Autophagy is a catabolic process through which cell entities …

MiR-155 inhibitor-laden exosomes reverse resistance to cisplatin in a 3D tumor spheroid and xenograft model of oral cancer

AA Sayyed, P Gondaliya, M Mali, A Pawar… - Molecular …, 2021 - ACS Publications
Cisplatin resistance is one of the major concerns in the treatment of oral squamous cell
carcinoma (OSCC). Accumulating evidence suggests microRNA (miRNA) dysregulation as …