Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the
nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm …

The genome is packaged and organized nonrandomly within the 3D space of the nucleus to
promote efficient gene expression and to faithfully maintain silencing of heterochromatin …

Over the past few years it has become evident that the intermediate filament proteins, the
types A and B nuclear lamins, not only provide a structural framework for the nucleus, but …

The nuclear lamins are type V intermediate filament proteins that are critically important for
the structural properties of the nucleus. In addition, they are involved in the regulation of …

Lamina-associated polypeptides (LAPS) lA, lB, lC, and 2 are integral membrane proteins of
the nuclear envelope associated with the nuclear lamina. Using in vitro assays, we show …

Nuclear lamins are components of the peripheral lamina that define the mechanical
properties of nuclei and tether heterochromatin to the periphery. A-type lamins localize also …

Chromatin is a dynamic structure composed of DNA, RNA, and proteins, regulating storage
and expression of the genetic material in the nucleus. Heterochromatin plays a crucial role …

Caenorhabditis elegans has a single lamin gene, designated lmn-1 (previously termed
CeLam-1). Antibodies raised against the lmn-1 product (Ce-lamin) detected a 64-kDa …

• The lamin molecule‐Domain organization of lamins‐Lamins are divided to type A and type
B‐Post‐translational processing of lamin molecules‐Lamin molecules in evolution• The …

Interaction of chromatin with the nuclear envelope and lamina is thought to help determine
higher order chromosome organization in the interphase nucleus. Previous studies have …