Insulin-secreting pancreatic β-cells play a critical role in blood glucose homeostasis and the
development of type 2 diabetes (T2D) in the context of insulin resistance. Based on data …

Islets of Langerhans are multicellular microorgans located in the pancreas that play a central
role in whole-body energy homeostasis. Through secretion of insulin and other hormones …

Pancreatic β-cells respond to metabolic stress by upregulating insulin secretion, however
the underlying mechanisms remain unclear. Here we show, in β-cells from overweight …

Aims: Glucose-stimulated insulin secretion (GSIS) in pancreatic β cells was expected to
enhance mitochondrial superoxide formation. Hence, we elucidated relevant redox …

Influencing the redox balance of pancreatic beta cells could be a promising strategy for the
treatment of diabetes. Nuclear factor erythroid 2p45‐related factor 2 (Nrf2) is present in beta …

Modern lifestyles, including lack of physical activity and poor nutritional habits, are driving
the rapidly increasing prevalence of obesity and type 2 diabetes. Increased levels of free …

The role of the endothelium is not just limited to acting as an inert barrier for facilitating blood
transport. Endothelial cells (EC s), through expression of a repertoire of angiocrine …

The clinical success rate of islet transplantation, namely independence from insulin
injections, is limited by factors that lead to graft failure, including inflammation, acute …

Reactive oxygen and nitrogen species (RONS) play an important role in the
pathophysiology of skeletal muscle and are involved in the regulation of intracellular …

Simple Summary Defective insulin secretion by pancreatic beta cells is key for the
development of type 2 diabetes but the precise mechanisms involved are poorly understood …