[HTML][HTML] Control compounds for preclinical drug-induced liver injury assessment: Consensus-driven systematic review by the ProEuroDILI network

A Segovia-Zafra, M Villanueva-Paz, AS Serras… - Journal of …, 2024 - Elsevier
Background & Aims Idiosyncratic drug-induced liver injury (DILI) is a complex and
unpredictable event caused by drugs, and herbal or dietary supplements. Early identification …

Bystander signaling via oxidative metabolism

HA Sawal, K Asghar, M Bureik, N Jalal - OncoTargets and therapy, 2017 - Taylor & Francis
The radiation-induced bystander effect (RIBE) is the initiation of biological end points in cells
(bystander cells) that are not directly traversed by an incident-radiation track, but are in close …

[HTML][HTML] Surface enhanced electrochemiluminescence of Ru (bpy) 32+

D Wang, L Guo, R Huang, B Qiu, Z Lin, G Chen - Scientific Reports, 2015 - nature.com
Surface enhanced spectroscopy such as surface enhanced Raman spectrum (SERS) and
surface enhanced fluorescence have been investigated extensively in the past two decades …

[HTML][HTML] Quantifying drug-induced structural toxicity in hepatocytes and cardiomyocytes derived from hiPSCs using a deep learning method

M Maddah, MA Mandegar, K Dame, F Grafton… - … of Pharmacological and …, 2020 - Elsevier
Cardiac and hepatic toxicity result from induced disruption of the functioning of
cardiomyocytes and hepatocytes, respectively, which is tightly related to the organization of …

An organizational approach for the assessment of DNA adduct data in risk assessment: case studies for aflatoxin B1, tamoxifen and vinyl chloride

LH Pottenger, LS Andrews, AN Bachman… - Critical reviews in …, 2014 - Taylor & Francis
The framework analysis previously presented for using DNA adduct information in the risk
assessment of chemical carcinogens was applied in a series of case studies which place the …

State-of-the-art metabolic toxicity screening and pathway evaluation

EG Hvastkovs, JF Rusling - 2016 - ACS Publications
Routine in vitro bioassays and animal toxicity studies of drug and environmental chemical
candidates fail to reveal toxicity in∼ 30% of cases. This Feature article addresses research …

Microfluidic electrochemical array for detection of reactive metabolites formed by cytochrome P450 enzymes

DP Wasalathanthri, V Mani, CK Tang… - Analytical …, 2011 - ACS Publications
A novel, simple, rapid microfluidic array using bioelectronically driven cytochrome P450
enzyme catalysis for reactive metabolite screening is reported for the first time. The device …

Metabolic Toxicity Screening Using Electrochemiluminescence Arrays Coupled with Enzyme-DNA Biocolloid Reactors and Liquid Chromatography–Mass …

EG Hvastkovs, JB Schenkman… - Annual Review of …, 2012 - annualreviews.org
New chemicals or drugs must be guaranteed safe before they can be marketed. Despite
widespread use of bioassay panels for toxicity prediction, products that are toxic to a subset …

Synthesis and characterization of vinyl-functionalized magnetic nanofibers for protein imprinting

Y Li, Q Bin, Z Lin, Y Chen, H Yang, Z Cai… - Chemical …, 2015 - pubs.rsc.org
Synthesis and characterization of vinyl-functionalized magnetic nanofibers for protein imprinting
- Chemical Communications (RSC Publishing) DOI:10.1039/C4CC05761A Royal Society of …

Advantages of human hepatocyte-derived transformants expressing a series of human cytochrome p450 isoforms for genotoxicity examination

T Hashizume, S Yoshitomi, S Asahi… - Toxicological …, 2010 - academic.oup.com
Metabolites of chemicals can often be ultimate genotoxic species; thus, in vitro routine
testing requires the use of rat liver S9. However, there is a question as to whether this …