The lymphatic vasculature has a pivotal role in regulating body fluid homeostasis, immune
surveillance and dietary fat absorption. The increasing number of in vitro and in vivo studies …

Lymphatic endothelial cells (LECs) lining lymphatic vessels develop specialized cell-cell
junctions that are crucial for the maintenance of vessel integrity and proper lymphatic …

Cerebrovascular dysregulation is a hallmark of Alzheimer's disease (AD), but the changes
that occur in specific cell types have not been fully characterized. Here, we profile single …

The strain 68-1 rhesus cytomegalovirus (RhCMV)–based vaccine for simian
immunodeficiency virus (SIV) can stringently protect rhesus macaques (RMs) from SIV …

Primary lymphedema is a long-term (chronic) condition characterized by tissue lymph
retention and swelling that can affect any part of the body, although it usually develops in the …

The lymphatic vascular system acts as the major transportation highway of tissue fluids, and
its activation or impairment is associated with a wide range of diseases. There has been …

During the growth of lymphatic vessels (lymphangiogenesis), lymphatic endothelial cells
(LECs) at the growing front sprout by forming filopodia. Those tip cells are not exposed to …

Endothelial integrity is vital for homeostasis and adjusted to tissue demands. Although fluid
uptake by lymphatic capillaries is a critical attribute of the lymphatic vasculature, the barrier …

BACKGROUND: Specialized valve endothelial cell (VEC) populations are localized oriented
to blood flow in developing aortic and mitral valves, but their roles in valve development and …

The molecular mechanisms by which lymphatic vessels induce cell contact inhibition are not
understood. Here, we identify the cGMP-dependent phosphodiesterase 2A (PDE2A) as a …