The urothelium, which lines the inner surface of the renal pelvis, the ureters, and the urinary
bladder, not only forms a high-resistance barrier to ion, solute and water flux, and …

▪ Abstract The detection of painful stimuli occurs primarily at the peripheral terminals of
specialized sensory neurons called nociceptors. These small-diameter neurons transduce …

The transient receptor potential (TRP) superfamily consists of a large number of cation
channels that are mostly permeable to both monovalent and divalent cations. The 28 …

神经源性膀胱(neurogenic bladder) 是一类由于神经系统病变导致膀胱和/或尿道功能障碍(即储
尿和/或排尿功能障碍), 进而产生一系列下尿路症状及并发症的疾病总称 …

Introduction The normal bladder functions, storage and elimination of urine, are based on a
coordinated interplay of reciprocal contraction and relaxation of the bladder and the outflow …

Purpose: We evaluated the efficacy of botulinum-A toxin injections into the detrusor muscle
in patients with spinal cord injury, detrusor hyperreflexia and urge incontinence resistant to …

Symptoms of overactive bladder are common, are often distressing, and may have serious
adverse consequences. Myriad factors—disorders of the lower urinary tract, neurologic …

Pungency in Capsicum fruits is due to the accumulation of the alkaloid capsaicin and its
analogs. The biosynthesis of capsaicin is restricted to the genus Capsicum and results from …

The present study explores the possible involvement of a purinergic mechanism in
mechanosensory transduction in the bladder using P2X3 receptor knock-out (P2X3−/−) and …

Although the urinary bladder urothelium has classically been thought of as a passive barrier
to ions and solutes, a number of novel properties have been recently attributed to urothelial …