Metastatic prostate cancer patients present in two ways—with already disseminated disease
at the time of presentation or with disease recurrence after definitive local therapy. Androgen …

Abstract Bisphosphonates (BP) prevent, reduce, and delay cancer-related skeletal
complications in patients, and have substantially decreased the prevalence of such events …

Cervical cancer is one of the gravest threats to women's lives. It is estimated that over a
million women worldwide currently have cervical cancer. Most of these women have not …

Background Mitoxantrone plus prednisone reduces pain and improves the quality of life in
men with advanced, hormone-refractory prostate cancer, but it does not improve survival …

Background Mitoxantrone-based chemotherapy palliates pain without extending survival in
men with progressive androgen-independent prostate cancer. We compared docetaxel plus …

Abstract Learning Objectives After completing this course, the reader will be able to: Explain
the importance of bone disease in the common solid tumors of adulthood. Describe the …

The presence of bone metastases is indicative of disseminated disease and typically
indicates a short-term prognosis in cancer patients. Palliation of symptoms is the primary …

Background and aims Bisphosphonates might be effective in reducing cardiovascular
events due to their ability to reduce calcification in arterial walls. We aimed to investigate the …

PURPOSE: This open-label phase II trial assessed mitoxantrone/prednisone (M/P) with and
without siltuximab (CNTO 328), an anti-interleukin-6 chimeric monoclonal antibody, for …

Abstract Introduction Skeletal-related events (SREs) from malignant bone disease cause
considerable morbidity and can dramatically reduce patients' quality of life. Discussion …