The remarkable plasticity of Schwann cells allows them to adopt the Remak (non-myelin)
and myelin phenotypes, which are specialized to meet the needs of small and large …

Schwann cells respond to nerve injury by cellular reprogramming that generates cells
specialized for promoting regeneration and repair. These repair cells clear redundant …

Schwann cells develop from the neural crest in a well-defined sequence of events. This
involves the formation of the Schwann cell precursor and immature Schwann cells, followed …

During the development of peripheral nerves, neural crest cells generate myelinating and
non-myelinating glial cells in a process that parallels gliogenesis from the germinal layers of …

Whereas the central nervous system (CNS) usually cannot regenerate, peripheral nerves
regenerate spontaneously after injury because of a permissive environment and activation …

In the peripheral nervous system, Schwann cells are glial cells that are in intimate contact
with axons throughout development. Schwann cells generate the insulating myelin sheath …

Sox proteins are characterized by possession of a DNA-binding domain with similarity to the
high-mobility group domain of the sex determining factor SRY. Here, we report on Sox10, a …

Axotomy or crush of a peripheral nerve leads to degeneration of the distal nerve stump
referred to as Wallerian degeneration (WD). During WD a microen‐vironment is created that …

Schwann cell incredible plasticity is a hallmark of the utmost importance following nerve
damage or in demyelinating neuropathies. After injury, Schwann cells undergo …

Dedifferentiation of myelinating Schwann cells is a key feature of nerve injury and
demyelinating neuropathies. We review recent evidence that this dedifferentiation depends …