Tip60's novel RNA-binding function modulates alternative splicing of pre-mRNA targets implicated in Alzheimer's disease
A Bhatnagar, K Krick, BC Karisetty… - Journal of …, 2023 - Soc Neuroscience
The severity of Alzheimer9s disease (AD) progression involves a complex interplay of
genetics, age, and environmental factors orchestrated by histone acetyltransferase (HAT) …
genetics, age, and environmental factors orchestrated by histone acetyltransferase (HAT) …
Decoding the genetic relationship between Alzheimer's disease and type 2 diabetes: potential risk variants and future direction for North Africa
W Boukhalfa, H Jmel, N Kheriji, I Gouiza… - Frontiers in Aging …, 2023 - frontiersin.org
Introduction Alzheimer's disease (AD) and Type 2 diabetes (T2D) are both age-associated
diseases. Identification of shared genes could help develop early diagnosis and preventive …
diseases. Identification of shared genes could help develop early diagnosis and preventive …
Simultaneous administration of bromodomain and histone deacetylase I inhibitors alleviates cognition deficit in Alzheimer's model of rats
Abstract Background Histone deacetylases (HDACs) target various genes responsible for
cognitive functions. However, chromatin readers, particularly bromodomain-containing …
cognitive functions. However, chromatin readers, particularly bromodomain-containing …
Transcriptomic analysis reveals nanoplastics-induced apoptosis, autophagy and immune response in Litopenaeus vannamei
Y Li, Y Ye, X Zhu, X Liu, X Li, Y Zhao, X Che - Science of The Total …, 2024 - Elsevier
Increasing attention is being paid to the toxic physiological effects of nanoplastics (NPs) on
aquatic organisms. However, few studies have systematically evaluated the regulatory …
aquatic organisms. However, few studies have systematically evaluated the regulatory …
Computational prognostic evaluation of Alzheimer's drugs from FDA-approved database through structural conformational dynamics and drug repositioning …
472a Wednesday, February 22, 2023 profiles. The possible associations of selected drugs
with AD related genes were predicted by pharmacogenomics analysis and confirmed …
with AD related genes were predicted by pharmacogenomics analysis and confirmed …
Prediction of site directed miRNAs as key players of transcriptional regulators against influenza C virus infection through computational approaches
MicroRNAs (miRNAs) are small non-coding RNAs that play critical roles in gene expression,
cell differentiation, and immunity against viral infections. In this study, we have used the …
cell differentiation, and immunity against viral infections. In this study, we have used the …
Dissecting the shared genetic architecture between Alzheimer's disease and frailty: a cross-trait meta-analyses of genome-wide association studies
Introduction: Frailty is the most common medical condition affecting the aging population,
and its prevalence increases in the population aged 65 or more. Frailty is commonly …
and its prevalence increases in the population aged 65 or more. Frailty is commonly …
Exploration of potential ewing sarcoma drugs from FDA-approved pharmaceuticals through computational drug repositioning, pharmacogenomics, molecular docking …
Novel drug development is a time-consuming process with relatively high debilitating costs.
To overcome this problem, computational drug repositioning approaches are being used to …
To overcome this problem, computational drug repositioning approaches are being used to …
Pharmacoinformatic Analysis of Drug Leads for Alzheimer's Disease from FDA-Approved Dataset Through Drug Repositioning Studies
Drug design is highly priced and time-consuming procedure. Therefore, to overcome this
problem, in silico drug design methods, particularly drug repositioning have been developed …
problem, in silico drug design methods, particularly drug repositioning have been developed …
Bioinformatics Analysis Provides Insight into the Identification of miRNAs as Transcriptional Regulators in Respiratory Syncytial Virus Infection
S Shahzadi, M Hassan, A Kloczkowski - International Work-Conference on …, 2024 - Springer
In children under five, the Respiratory Syncytial Virus (RSV) is a leading global cause of
severe lower respiratory tract infections. Due to medical significance of this problem, the …
severe lower respiratory tract infections. Due to medical significance of this problem, the …