The glycome describes the complete repertoire of glycoconjugates composed of
carbohydrate chains, or glycans, that are covalently linked to lipid or protein molecules …

Helping B cells and antibody responses is a major function of CD4+ T cells. It has been 10
years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular …

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. As a
result of the coronavirus disease 2019 (COVID-19) pandemic, the global TB mortality rate in …

Vaccines activate suitable immune responses to fight against diseases but can possess
limitations such as compromised efficacy and immunogenic responses, poor stability, and …

Glycans–simple or complex carbohydrates–play key roles as recognition determinants and
modulators of numerous physiological and pathological processes. Thus, many …

Introduction: Over the last decades, glycoconjugate vaccines have been proven to be a
successful strategy to prevent infectious diseases. Many diseases remain to be controlled …

The surface of cells is coated with a dense layer of glycans, known as the cell glycocalyx.
The complex glycans in the glycocalyx are involved in various biological events, such as …

Humoral immune responses to microbial polysaccharide surface antigens can prevent
bacterial infection but are typically strain specific and fail to mediate broad protection against …

Introduction Antimicrobial resistance (AMR) is responsible for the death of millions
worldwide and stands as a major threat to our healthcare systems, which are heavily reliant …

Glycoconjugate vaccines obtained by chemical linkage of a carbohydrate antigen to a
protein are part of routine vaccinations in many countries. Licensed antimicrobial glycan …