Many anticancer immunotherapeutic agents, including the monoclonal immune checkpoint
blocking antibodies, toll-like receptor (TLR) agonists, cytokines and immunostimulatory …

IL-36 belongs to the IL-1 family of cytokines and activates target cells by binding to a specific
cytokine receptor (IL-36R) followed by activation of intracellular regulators such as MAP …

Interleukin (IL)-38, a novel member of the IL-1 cytokine family, is homologous to IL-1
receptor antagonist (IL-1Ra) and IL-36Ra, and has been reported to act as an antagonist. IL …

Results Out of 503 studies searched in databases, 18 studies were included in the meta-
analysis. The pooled analysis with continuous data demonstrated that the IL-6 level in HCC …

Colorectal cancer (CRC) is still a big killer nowadays, but the precise underlying mechanism
remains to be explored. It is believed that imbalance of host immunity in the local …

Background and aims Colorectal cancer (CRC) is a major killer. Host immunity is important
in tumorigenesis. Direct comparison among IL-36α, IL-36β and IL-36γ in the prognosis of …

Abstract CD134-and CD137-primed CD8 T cells mount powerful effector responses upon
recall, but even without recall these dual-costimulated T cells respond to signal 3 cytokines …

Melatonin is a pleiotropic anti-cancer molecule that controls cancer growth by multiple
mechanisms. RNA-Seq can potentially evaluate therapeutic response and its use in …

Objective: To investigate the effect of long noncoding RNA GM16343 on interleukin 36β
promotion of CD8+ T cells in tumor microenvironment regulation. Methods: The differentially …

The ability of the immune system to prevent or control the growth of tumor cells is critically
dependent on inflammatory processes that lead to the activation, expansion, and recruitment …