Background The early life environment experienced by an individual in utero and during the
neonatal period is a major factor in shaping later life disease risk-including susceptibility to …

The type 2 diabetes epidemic and one of its predisposing factors, obesity, are major
influences on global health and economic burden. It is accepted that genetics and the …

Complex multicellular organisms require a coordinated response from multiple tissues to
maintain whole-body homeostasis in the face of energetic stressors such as fasting, cold …

Maternal and paternal obesity and type 2 diabetes are recognized risk factors for the
development of metabolic dysfunction in offspring, even when the offspring follow a healthful …

Poor maternal diet increases the risk of obesity and type 2 diabetes in offspring, adding to
the ever-increasing prevalence of these diseases. In contrast, we find that maternal exercise …

Epigenetics can be defined as 'the structural adaptation of chromosomal regions so as to
register, signal, or perpetuate altered activity states.'Increased transcription of key regulatory …

The obesity epidemic has led to more women entering pregnancy overweight or obese. In
addition to adverse short‐term outcomes, maternal obesity and/or gestational diabetes …

Globally, cardiovascular disease remains the leading cause of death. Most concerning is the
rise in cardiovascular risk factors including obesity, diabetes and hypertension among youth …

The obesity rate is rapidly increasing, which has been attributed to lack of exercise and
excessive energy intake. Here, we found a previously unidentified explanation, due to lack …

Poor paternal diet has emerged as a risk factor for metabolic disease in offspring, and
alterations in sperm may be a major mechanism mediating these detrimental effects of diet …