Phage display technology can be used for the discovery of antibodies for research,
diagnostic, and therapeutic purposes. In this review, we present and discuss key parameters …

Since the 2013 Nobel Prize was awarded for the discovery of vesicle trafficking, a subgroup
of nanovesicles called exosomes has been driving the research field to a new regime for …

Targeting the tumor vasculature with antibody-drug conjugates (ADCs) is a promising anti-
cancer strategy that in order to be realized must overcome several obstacles, including …

Here, we propose a new model for understanding the Warburg effect in tumor metabolism.
Our hypothesis is that epithelial cancer cells induce the Warburg effect (aerobic glycolysis) …

Nanoparticles have shown promise as both drug delivery vehicles and direct antitumor
systems, but they must be properly designed in order to maximize efficacy. Computational …

Endothelial cells, which form the inner cellular lining of blood vessels and lymphatics,
display remarkable heterogeneity in structure and function. This is the first of a 2-part review …

The various types of cells that comprise the tumor mass all carry molecular markers that are
not expressed or are expressed at much lower levels in normal cells. These differentially …

With 18 monoclonal antibody (mAb) products currently on the market and more than 100 in
clinical trials, it is clear that engineered antibodies have come of age as biopharmaceuticals …

Applications of nanotechnology for treatment, diagnosis, monitoring, and control of
biological systems has recently been referred to as “nanomedicine” by the National Institutes …

Endothelial cells, which form the inner cellular lining of blood vessels and lymphatics,
display remarkable heterogeneity in structure and function. This is the second of a 2-part …