Vitamin C and immune cell function in inflammation and cancer
Vitamin C (ascorbate) is maintained at high levels in most immune cells and can affect many
aspects of the immune response. Intracellular levels generally respond to variations in …
aspects of the immune response. Intracellular levels generally respond to variations in …
Epigenetic control of myeloid cell differentiation, identity and function
Myeloid cells are crucial effectors of the innate immune response and important regulators of
adaptive immunity. The differentiation and activation of myeloid cells requires the timely …
adaptive immunity. The differentiation and activation of myeloid cells requires the timely …
Transcriptional networks driving dendritic cell differentiation and function
Dendritic cells (DCs) are the sentinels of the immune system, sensing a diverse array of
pathogens to stimulate a robust and appropriate immune response. To initiate responses to …
pathogens to stimulate a robust and appropriate immune response. To initiate responses to …
[HTML][HTML] Epigenetic strategies synergize with PD-L1/PD-1 targeted cancer immunotherapies to enhance antitumor responses
X Chen, X Pan, W Zhang, H Guo, S Cheng, Q He… - … Pharmaceutica Sinica B, 2020 - Elsevier
Immunotherapy strategies targeting the programmed cell death ligand 1 (PD-
L1)/programmed cell death 1 (PD-1) pathway in clinical treatments have achieved …
L1)/programmed cell death 1 (PD-1) pathway in clinical treatments have achieved …
Role of methylation in pro-and anti-cancer immunity
A Mehdi, SA Rabbani - Cancers, 2021 - mdpi.com
Simple Summary Epigenetic mechanisms including methylation play an essential role in
regulating gene expression not only in cancer cells but also in immune cells. Although role …
regulating gene expression not only in cancer cells but also in immune cells. Although role …
Gene activation precedes DNA demethylation in response to infection in human dendritic cells
A Pacis, F Mailhot-Léonard, L Tailleux… - Proceedings of the …, 2019 - National Acad Sciences
DNA methylation is considered to be a relatively stable epigenetic mark. However, a
growing body of evidence indicates that DNA methylation levels can change rapidly; for …
growing body of evidence indicates that DNA methylation levels can change rapidly; for …
DNA methylation–based immune response signature improves patient diagnosis in multiple cancers
BACKGROUND. The tumor immune response is increasingly associated with better clinical
outcomes in breast and other cancers. However, the evaluation of tumor-infiltrating …
outcomes in breast and other cancers. However, the evaluation of tumor-infiltrating …
Prostaglandin E2 leads to the acquisition of DNMT3A-dependent tolerogenic functions in human myeloid-derived suppressor cells
J Rodríguez-Ubreva, F Català-Moll, N Obermajer… - Cell reports, 2017 - cell.com
Myeloid-derived suppressor cells (MDSCs) and dendritic cells (DCs) arise from common
progenitors. Tumor-derived factors redirect differentiation from immune-promoting DCs to …
progenitors. Tumor-derived factors redirect differentiation from immune-promoting DCs to …
Reshaping the tumour immune microenvironment in solid tumours via tumour cell and immune cell DNA methylation: from mechanisms to therapeutics
F Zhong, Y Lin, L Zhao, C Yang, Y Ye… - British Journal of Cancer, 2023 - nature.com
In recent years, the tumour microenvironment (TME) of solid tumours has attracted more and
more attention from researchers, especially those non-tumour components such as immune …
more attention from researchers, especially those non-tumour components such as immune …
Understanding the relevance of DNA methylation changes in immune differentiation and disease
Immune cells are one of the most complex and diverse systems in the human organism.
Such diversity implies an intricate network of different cell types and interactions that are …
Such diversity implies an intricate network of different cell types and interactions that are …