IL-12 and IL-23 pathway inhibition in inflammatory bowel disease
Abstract Interleukin-12 (IL-12) and interleukin-23 (IL-23), which belong to the IL-12 family of
cytokines, have a key role in intestinal homeostasis and inflammation and are implicated in …
cytokines, have a key role in intestinal homeostasis and inflammation and are implicated in …
Understanding and preventing the global increase of inflammatory bowel disease
The inflammatory bowel diseases (IBDs) are contemporary conditions of industrialized
societies. The prevalence of IBD continues to increase steadily in Western countries, and …
societies. The prevalence of IBD continues to increase steadily in Western countries, and …
Crohn's disease
J Torres, S Mehandru, JF Colombel, L Peyrin-Biroulet - The Lancet, 2017 - thelancet.com
Crohn's disease is a chronic inflammatory disease of the gastrointestinal tract, with
increasing incidence worldwide. Crohn's disease might result from a complex interplay …
increasing incidence worldwide. Crohn's disease might result from a complex interplay …
Functions and regulation of T cell-derived interleukin-10
Abstract Interleukin (IL)-10 is an essential anti-inflammatory cytokine and functions as a
negative regulator of immune responses to microbial antigens. IL-10 is particularly important …
negative regulator of immune responses to microbial antigens. IL-10 is particularly important …
Effects of race and ethnicity on diagnosis and management of inflammatory bowel diseases
EL Barnes, EV Loftus Jr, MD Kappelman - Gastroenterology, 2021 - Elsevier
Although Crohn's disease (CD) and ulcerative colitis (UC) have been considered as
disorders that affect individuals of European ancestry, the epidemiology of the inflammatory …
disorders that affect individuals of European ancestry, the epidemiology of the inflammatory …
[HTML][HTML] A decade of research on the 17q12-21 asthma locus: piecing together the puzzle
MM Stein, EE Thompson, N Schoettler… - Journal of Allergy and …, 2018 - Elsevier
Chromosome 17q12-21 remains the most highly replicated and significant asthma locus.
Genotypes in the core region defined by the first genome-wide association study correlate …
Genotypes in the core region defined by the first genome-wide association study correlate …
[HTML][HTML] Inflammatory bowel disease and primary sclerosing cholangitis: a review of the phenotype and associated specific features
C Palmela, F Peerani, D Castaneda, J Torres… - Gut and liver, 2018 - ncbi.nlm.nih.gov
Primary sclerosing cholangitis (PSC) is a chronic, progressive cholestatic disease that is
associated with inflammatory bowel disease (IBD) in approximately 70% of cases. Although …
associated with inflammatory bowel disease (IBD) in approximately 70% of cases. Although …
Diet, gut microbes, and the pathogenesis of inflammatory bowel diseases
KT Dolan, EB Chang - Molecular nutrition & food research, 2017 - Wiley Online Library
The rising incidence of inflammatory bowel diseases in recent decades has notably
paralleled changing lifestyle habits in Western nations, which are now making their way into …
paralleled changing lifestyle habits in Western nations, which are now making their way into …
[HTML][HTML] Differential regulation of JAK/STAT-signaling in patients with ulcerative colitis and Crohn's disease
F Cordes, D Foell, JN Ding, G Varga… - World journal of …, 2020 - ncbi.nlm.nih.gov
In 2018, the pan-Janus kinase (JAK) inhibitor tofacitinib was launched for the treatment of
ulcerative colitis (UC). Although tofacitinib has proven efficacious in patients with active UC …
ulcerative colitis (UC). Although tofacitinib has proven efficacious in patients with active UC …
[HTML][HTML] Differentiating gastrointestinal tuberculosis and Crohn's disease-a comprehensive review
Abstract Gastrointestinal Tuberculosis (GITB) and Crohn's disease (CD) are both chronic
granulomatous diseases with a predilection to involve primarily the terminal ileum. GITB is …
granulomatous diseases with a predilection to involve primarily the terminal ileum. GITB is …