Over the past two decades a growing body of evidence has demonstrated an important role
of tight junction (TJ) proteins in the physiology and disease biology of GI and liver disease …

Claudins are tight junction membrane proteins that are expressed in epithelia and
endothelia and form paracellular barriers and pores that determine tight junction …

The tight junction creates an intercellular barrier limiting paracellular movement of solutes
and material across epithelia. Currently many proteins have been identified as components …

Dengue is the most prevalent arthropod-borne viral disease, caused by dengue virus, a
member of the Flaviviridae family. Its worldwide incidence is now a major health problem …

Hepatocellular carcinoma (HCC), also called malignant hepatoma, is one of the deadliest
cancers due to its complexities, reoccurrence after surgical resection, metastasis and …

The epithelial-mesenchymal transition (EMT) is an essential step in cancer progression.
Epithelial cells possess several types of cell-cell junctions, and tight junctions are known to …

Hepatitis C virus (HCV) is a major cause of liver disease, but therapeutic options are limited
and there are no prevention strategies. Viral entry is the first step of infection and requires …

Hepatitis C virus (HCV) is an important human pathogen that causes hepatitis, liver cirrhosis
and hepatocellular carcinoma. It imposes a serious problem to public health in the world as …

The cell imposes multiple barriers to virus entry. However, viruses exploit fundamental
cellular processes to gain entry to cells and deliver their genetic cargo. Virus entry pathways …

Hepatitis C virus, a major human pathogen, produces infectious virus particles with several
unique features, such as an ability to interact with serum lipoproteins, a dizzyingly …