Many are frustrated with the lack of translational progress in the pain field, in which huge
gains in basic science knowledge obtained using animal models have not led to the …

Background Calcitonin gene-related peptide (CGRP) is widely distributed in nociceptive
pathways in human peripheral and central nervous system and its receptors are also …

The cellular and molecular mechanisms mediating histamine-independent itch in primary
sensory neurons are largely unknown. Itch induced by chloroquine (CQ) is a common side …

Calcitonin gene-related peptide (CGRP) has been detected in increased amounts in
external jugular venous blood during migraine attacks. However, it is unknown whether this …

1. Introduction......................................... II. Anatomy and physiology................................ A. The
peripheral apparatus............................. Fiber composition of muscle nerves …

2. Tachykinins and CGRP in primary afferent neurons 2.1. Synthesis and expression of
tachykinins 2.2. Svnthesis and exnression of CGRP 2.3. Co-localization of tachykinins and …

The nature of dorsal root reflexes (DRRs) and their possible role in peripheral inflammation
and the consequent hyperalgesia are reviewed. The history of DRRs and the relationship of …

Migraine is a highly prevalent neurovascular disorder that can be provoked by infusion of
calcitonin gene-related peptide (CGRP). CGRP, a neuropeptide released from activated …

Migraine is a strongly disabling disease characterized by a unilateral throbbing headache
lasting for up to 72 h for each individual attack. There have been many theories on the …

Nitric oxide (NO) may play a key role in migraine and other vascular headaches since
glyceryl trinitrate (a dorzor of NO) and histamine Czuhich probnbly activates endothelial NO …