While originally characterized as a collection of related syndromes, cystic fibrosis (CF) is
now recognized as a single disease whose diverse symptoms stem from the wide tissue …

The colonic epithelium has both absorptive and secretory functions. The transport is
characterized by a net absorption of NaCl, short-chain fatty acids (SCFA), and water …

Overlapping complementary DNA clones were isolated from epithelial cell libraries with a
genomic DNA segment containing a portion of the putative cystic fibrosis (CF) locus, which is …

An understanding of the basic defect in the inherited disorder cystic fibrosis requires cloning
of the cystic fibrosis gene and definition of its protein product. In the absence of direct …

CFTR, the protein associated with cystic fibrosis, is phosphorylated on serine residues in
response to CAMP agonists. Serines 660, 737, 795, and 613 were identified as in vivo …

Direct transfer of the normal cystic fibrosis (CF) transmembrane conductance regulator
(CFTR) gene to airway epitheiium was evaluated using a replicationdeficient recombinant …

Adeno-associated virus type 2 (AAV) vectors have been used for gene expression in
respiratory epithelial cells and may be useful in gene therapy for diseases like cystic fibrosis …

Embryonic spinal motor neurons are thought to depend for survival on unidentified factors
secreted both by their peripheral targets and by cells within the central nervous system1 …

THE phenotype of cystic fibrosis (CF) includes abnormalities in transepithelial transport of Cl-
(refs 1–5), decreased sialylation and increased sulphation and fucosylation of …

ENDOTHELIAL cell leukocyte adhesion molecule-1 (ELAM-1) has been described as an
inducible endothelial cell-adhesion molecule for neutrophils, and is believed to have a key …