Recent developments in catalytic asymmetric aldol reactions have been summarized.
Enantioselective aldol reactions are important methods to synthesize β-hydroxy carbonyl …

Carbon–carbon bond formation is the key reaction for organic synthesis to construct the
carbon framework of organic molecules. The review gives a selection of biocatalytic C–C …

Ethylene glycol is an attractive two-carbon alcohol substrate for biochemical product
synthesis as it can be derived from CO2 or syngas at no sacrifice to human food stocks …

Enantiomerically pure alcohols, as key intermediates, play an essential role in the
pharmaceutical, agrochemical and chemical industries. Among the methods used for their …

The preparation of multifunctional chiral molecules can be greatly simplified by adopting a
route via the sequential catalytic assembly of achiral building blocks. The catalytic aldol …

Application of aldolases for the asymmetric synthesis of multifunctional chiral products is
hampered by their reputed strict nucleophile (= aldol donor) specificity owing to a …

Modulation of enzyme activity is a powerful means of probing cellular function and can be
exploited for diverse applications. Here, we explore a method of enzyme activation where …

Asymmetric aldol addition of simple aldehydes and ketones to electrophiles is a cornerstone
reaction for the synthesis of unusual sugars and chiral building blocks. We investigated d …

An A129G/R134V/S166G triple mutant of fructose 6-phosphate aldolase (FSA) from
Escherichia coli was further engineered with the goal to generate new enzyme variants …

The 2C-methyl-d-erythritol-4-phosphate (MEP) pathway in Escherichia coli has been
highlighted for its potential to provide access to myriad isoprenoid chemicals of industrial …