Intermuscular adipose tissue in metabolic disease

BH Goodpaster, BC Bergman, AM Brennan… - Nature Reviews …, 2023 - nature.com
Intermuscular adipose tissue (IMAT) is a distinct adipose depot described in early reports as
a 'fatty replacement'or 'muscle fat infiltration'that was linked to ageing and neuromuscular …

Effects of exercise and aging on skeletal muscle

G Distefano, BH Goodpaster - Cold Spring …, 2018 - perspectivesinmedicine.cshlp.org
A substantial loss of muscle mass and strength (sarcopenia), a decreased regenerative
capacity, and a compromised physical performance are hallmarks of aging skeletal muscle …

Gender and sex differences in adipose tissue

E Chang, M Varghese, K Singer - Current diabetes reports, 2018 - Springer
Abstract Purpose of Review As the ongoing epidemic of adult and childhood obesity grows,
it puts a greater burden on individuals and the healthcare system due to increased …

Dissecting adipose tissue lipolysis: molecular regulation and implications for metabolic disease

TS Nielsen, N Jessen, JOL Jørgensen… - Journal of …, 2014 - jme.bioscientifica.com
Lipolysis is the process by which triglycerides (TGs) are hydrolyzed to free fatty acids (FFAs)
and glycerol. In adipocytes, this is achieved by sequential action of adipose TG lipase …

Fasting insulin, insulin resistance and risk of hypertension in the general population: a meta-analysis

F Wang, L Han, D Hu - Clinica chimica acta, 2017 - Elsevier
Background Studies on the association of fasting insulin concentrations or insulin resistance
with subsequent risk of hypertension have yielded conflicting results. Objective To …

[HTML][HTML] Sex dimorphism and depot differences in adipose tissue function

UA White, YD Tchoukalova - … et Biophysica Acta (BBA)-Molecular Basis of …, 2014 - Elsevier
Obesity, characterized by excessive adiposity, is a risk factor for many metabolic
pathologies, such as type 2 diabetes mellitus (T2DM). Numerous studies have shown that …

Relationship of weight, height, and body mass index with fracture risk at different sites in postmenopausal women: the Global Longitudinal study of Osteoporosis in …

JE Compston, J Flahive, DW Hosmer… - Journal of bone and …, 2014 - academic.oup.com
Low body mass index (BMI) is a well‐established risk factor for fracture in postmenopausal
women. Height and obesity have also been associated with increased fracture risk at some …

Associations of abdominal subcutaneous and visceral fat with insulin resistance and secretion differ between men and women: the Netherlands epidemiology of …

R de Mutsert, K Gast, R Widya, E de Koning… - … syndrome and related …, 2018 - liebertpub.com
Background: Abdominal obesity is a well-established risk factor for the development of type
2 diabetes. However, sex differences may exist. We aimed to investigate the associations of …

[HTML][HTML] Body composition analysis in the pediatric population

DR Weber, MB Leonard, BS Zemel - … endocrinology reviews: PER, 2012 - ncbi.nlm.nih.gov
Body composition analysis has become a useful tool in both clinical and research settings.
Its use in the pediatric population is complicated by the rapid periods of growth and physical …

Shaping fat distribution: new insights into the molecular determinants of depot‐and sex‐dependent adipose biology

SK Fried, MJ Lee, K Karastergiou - Obesity, 2015 - Wiley Online Library
Objective To review recent advances in understanding the cellular mechanisms that
regulate fat distribution. Methods In this review, new insights into depot and sex differences …