Interleukins (ILs) are key mediators in the chronic vascular inflammatory response
underlying several aspects of cardiovascular disease. Due to their powerful pro …

Duchenne muscular dystrophy (DMD) is caused by mutations in the dystrophin gene that
result in the absence of functional protein. In the majority of cases these are out-of-frame …

Protein–protein interactions between members of the Myc transcription factor network are
potential targets of small molecule inhibitors and stabilizers. Diverse screening strategies …

The introduction and widespread use of coronary stents have been the most important
advancement in the percutaneous treatment of coronary artery disease since the …

Abstract Background Antisense oligonucleotides (AOs) can interfere with exon recognition
and intron removal during pre-mRNA processing, and induce excision of a targeted exon …

Antisense oligodeoxynucleotides targeting the mRNA of the gap junction protein Cx43
promote tissue repair in a variety of different wounds. Delivery of the antisense drug has …

Expression of alternatively spliced mRNA variants at specific stages of development or in
specific cells and tissues contributes to the functional diversity of the human genome …

AIM OF THE STUDY: The inhibitive effect of BuYang HuanWu Decoction (BYHWD) and its
major components on vascular intimal hyperplasia and the expressions of cell cycle protein …

This study addresses whether pathological levels of cyclic strain activate the c-Myc
promoter, leading to c-Myc transcription and downstream gene induction in human umbilical …

Antisense oligomers initially showed promise as compounds to modify gene expression,
primarily through RNaseH induced degradation of the target transcript. Expansion of the …