The serotonin (5-HT) hypothesis of schizophrenia arose from early studies on interactions
between the hallucinogenic drug LSD (d-lysergic acid diethylamide) and 5-HT in peripheral …

Objective Suicide is a major public health concern as each year 30000 people die by
suicide in the USA alone. In the teenage population, it is the second leading cause of death …

The effects of the indolehallucinogen psilocybin, a mixed 5-HT 2 and 5-HT 1 agonist, on
regional cerebral glucose metabolism were investigated in 10 healthy volunteers with PET …

Serotonergic dysfunction is thought to contribute to the pathophysiology of schizophrenia but
the evidence has not been systematically synthesised before. We therefore systematically …

Background Major depression and suicide are associated with fewer serotonin transporter
(5-HTT) sites. The 5′-flanking promoter region of the 5-HTT gene has a biallelic …

The modulating effects of serotonin on dopamine neurotransmission are not well
understood, particularly in acute psychotic states. Positron emission tomography was used …

Increasing evidence from neuroimaging and behavioral studies suggests that functional
disturbances within cortico-striato-thalamic pathways are critical to psychotic symptom …

Numerous abnormalities have been found in the serotonergic system in suicide attempters
and completers. There is considerable evidence that the serotonergic system is partly under …

Estrogen exerts profound effects on mood, mental state and memory by acting on both
“classical” monoamine and neuropeptide transmitter mechanisms in brain. Here we review …

Serotonin (5-hydroxytryptamine, 5-HT), the “happy hormone,” has a phylogenetically ancient
role in neural transmission (Turlejski, 1996). Because the serotonergic system has a …