Antiepileptic drugs (AEDs) have many benefits but also many side effects, including
aggression, agitation, and irritability, in some patients with epilepsy. This article offers a …

The mammalian genome contains four genes encoding GABA transporters (GAT1, slc6a1;
GAT2, slc6a13; GAT3, slc6a11; BGT1, slc6a12) and five glutamate transporter genes …

The concept of bioisosterism and the implementation of bioisosteric replacement is
fundamental to medicinal chemistry. The exploration of bioisosteres is often used to probe …

The “receiver operating characteristic”(ROC) curve method is a well-recognized metric used
as an objective way to evaluate the ability of a given test to discriminate between two …

This review considers how recent advances in the physiology of ion channels and other
potential molecular targets, in conjunction with new information on the genetics of idiopathic …

Glutamate is the principal excitatory neurotransmitter in the brain. Knowledge of the
glutamatergic synapse has advanced enormously over the last 10 years, primarily through …

Epilepsy, a disorder of recurrent seizures, is a common and frequently devastating
neurological condition. Available therapy is only symptomatic and often ineffective …

Family C of G-protein coupled receptors (GPCRs) from humans is constituted by eight
metabotropic glutamate (mGlu1-8) receptors, two heterodimeric-aminobutyric acidB …

Epilepsy is a common neurological disease but the mechanism of seizure generation has
been only partially unraveled. Furthermore, almost 30% of epileptic patients are resistant to …

Almost 25 years after the first report that glutamate can activate receptors coupled to
heterotrimeric G-proteins, tremendous progress has been made in the field of metabotropic …