For this GeneReview, the term" isolated methylmalonic acidemia" refers to a group of inborn
errors of metabolism associated with elevated methylmalonic acid (MMA) concentration in …

Newborn screening (NBS) was established as a public health program in the 1960s and is
crucial for facilitating detection of certain medical conditions in which early intervention can …

Deciphering the mechanisms of bacterial fatty acid biosynthesis is crucial for both the
engineering of bacterial hosts to produce fatty acid-derived molecules and the development …

Malonic aciduria is an extremely rare inborn error of metabolism due to malonyl-CoA
decarboxylase deficiency. This enzyme is encoded by the MLYCD (Malonyl-CoA …

The unusual feature of at-butyl group is found in several marine-derived natural products
including apratoxin A, a Sec61 inhibitor produced by the cyanobacterium Moorea bouillonii …

Natural product biosynthetic pathways contain a plethora of enzymatic tools to carry out
difficult biosynthetic transformations. Here, we discover an unusual mononuclear iron …

Acetyl coenzyme A (acetyl-CoA), a pivotal regulatory metabolite, is a product of numerous
catabolic reactions and a substrate for various anabolic responses. Its role extends to crucial …

Natural product biosynthetic pathways are replete with enzymes repurposed for new
catalytic functions. In some modular polyketide synthase (PKS) pathways, a GCN5-related N …

Pseudomonas species and other aerobic bacteria have a biotin-independent malonate
decarboxylase that is crucial for their utilization of malonate as the sole carbon and energy …

The biosynthesis of isopentenyl diphosphate, a fundamental precursor for isoprenoids, via
the mevalonate pathway is completed by diphosphomevalonate decarboxylase. This …