Ozone (O3) in the troposphere is an air pollutant and a greenhouse gas. In mainland China,
after the Air Pollution Prevention and Action Plan was implemented in 2013—and despite …

Oxidative stress plays an important role in the pathogenesis of chronic obstructive
pulmonary disease (COPD) caused by cigarette smoke and characterized by chronic …

Abstract Interleukin (IL)-1β, a pro-inflammatory cytokine, was elevated and participates in
periodontitis. Not only the link between IL-1β and periodontitis was proved by clinical …

Ambient air pollution is a leading environmental cause of morbidity and mortality globally
with most of the outcomes of cardiovascular origin. While numerous mechanisms are …

Elevated mitochondrial matrix superoxide and/or hydrogen peroxide concentrations drive a
wide range of physiological responses and pathologies. Concentrations of superoxide and …

Background. Traumatic brain injury (TBI) refers to temporary or permanent damage to brain
function caused by penetrating objects or blunt force trauma. TBI activates inflammasome …

Chronic obstructive pulmonary disease (COPD) is a progressive lung disorder with
substantial patient burden and leading cause of death globally. Cigarette smoke remains to …

Highlights•MtROS-NLRP3 inflammasome pathway plays an important role in arsenic-
induced hepatic insulin resistance (IR).•Activation of NLRP3 inflammasome in arsenic …

Emerging evidence indicates that NOD-like receptor protein 3 (NLRP3) inflammasome-
induced inflammation plays a critical role in the pathogenesis of rheumatoid arthritis (RA) …

Reactive oxygen species (ROS), either derived from exogenous sources or overproduced
endogenously, can disrupt the body's antioxidant defenses leading to compromised redox …