Therapeutic deep eutectic solvents: A comprehensive review of their thermodynamics, microstructure and drug delivery applications

MM Abdelquader, S Li, GP Andrews… - European Journal of …, 2023 - Elsevier
Deep eutectic solvents (DES) are multicomponent liquids that are usually formed by
coupling a hydrogen bond donor and acceptor leading to strong non-covalent (NC) …

Eutectic mixtures as an approach to enhance solubility, dissolution rate and oral bioavailability of poorly water-soluble drugs

GC Bazzo, BR Pezzini, HK Stulzer - International Journal of Pharmaceutics, 2020 - Elsevier
Eutectic mixtures have been known for a long time in the pharmaceutical field. However, its
potential as a system to improve the solubility and dissolution of poorly water-soluble drugs …

Applications of deep eutectic solvents related to health, synthesis, and extraction of natural based chemicals

L Lomba, CB García, MP Ribate, B Giner, E Zuriaga - Applied Sciences, 2021 - mdpi.com
Deep eutectic solvents are liquid mixtures of solid components at room temperature, which
present exceptional properties: high solvent capacity, high biodegradation, low volatile …

Strategies for Improving Transdermal Administration: New Approaches to Controlled Drug Release

O Dumitriu Buzia, AM Păduraru, CS Stefan, M Dinu… - Pharmaceutics, 2023 - mdpi.com
In this work, we aim to address several strategies to improve transdermal drug delivery, such
as iontophoresis, sonophoresis, electroporation and micron. We also propose a review of …

[HTML][HTML] Strategies for Improving Transdermal Administration: New Approaches to Controlled Drug Release

OD Buzia, AM Păduraru, CS Stefan, M Dinu… - …, 2023 - ncbi.nlm.nih.gov
In this work, we aim to address several strategies to improve transdermal drug delivery, such
as iontophoresis, sonophoresis, electroporation and micron. We also propose a review of …

[HTML][HTML] Cubosomes for enhancing intestinal absorption of fexofenadine hydrochloride: in situ and in vivo investigation

AA Sultan, NF El Nashar, SM Ashmawy… - International Journal …, 2022 - ncbi.nlm.nih.gov
Purpose The aim of this work was to probe cubosomes for enhanced intestinal absorption
and oral bioavailability of poorly absorbable fexofenadine HCl (FEX-HCl). Materials and …

Lidocaine as eutectic forming drug for enhanced transdermal delivery of nonsteroidal anti-inflammatory drugs

HF Marei, MF Arafa, EA Essa… - Journal of Drug Delivery …, 2021 - Elsevier
Co-application of local anesthetics as lidocaine and nonsteroidal anti-inflammatory drugs
(NSAIDs) can enhance local analgesia. Co-formulation of lidocaine with NSAIDs can …

Physicochemical Properties and Transdermal Absorption of a Flurbiprofen and Lidocaine Complex in the Non-Crystalline Form

Q Xu, T Furuishi, K Fukuzawa, E Yonemochi - Pharmaceutics, 2023 - mdpi.com
Amorphous drug formulations exploiting drug–drug interactions have been extensively
studied. This study aims to develop a transdermal system containing an amorphous complex …

[HTML][HTML] Development of a novel intramuscular liposomal injection for advanced meloxicam delivery: Preparation, characterization, in vivo pharmacokinetics …

PA Hanna, HA Al-Abbadi, MA Hashem… - International Journal of …, 2024 - Elsevier
Pain produces several physiological, and degenerative complications. This study aimed to
formulate meloxicam (MLX) in liposomes to increase solubility and deliver MLX in a …

Lopinavir-menthol co-crystals for enhanced dissolution rate and intestinal absorption

ND Fayed, MF Arafa, EA Essa… - Journal of Drug Delivery …, 2022 - Elsevier
Lopinavir is an antiretroviral, antiparasitic agent and recently utilized in treatment of COVID-
19. Unfortunately, lopinavir exhibited poor oral bioavailability due to poor dissolution …