Genetic analysis of autoimmune disease

TJ Vyse, JA Todd - Cell, 1996 - cell.com
Genetic Analysis of Autoimmune Disease: Cell Skip to Main Content Advertisement Cell This
journal offers authors two options (open access or subscription) to publish research Submit …

Molecular physiology of vertebrate Na+/H+ exchangers

S Wakabayashi, M Shigekawa… - Physiological …, 1997 - journals.physiology.org
This review describes recent progress concerning the molecular aspects of the Na+/H+
exchanger. The Na+/H+ exchanger is an important regulator for intracellular pH, cell volume …

Genetic control of autoimmune diabetes in the NOD mouse.

LS Wicker, JA Todd, LB Peterson - Annual review of immunology, 1995 - europepmc.org
The nonobese diabetic (NOD) mouse is a model of human autoimmune insulin-dependent
diabetes mellitus. The NOD mouse also serves as a model for studying complex polygenic …

[图书][B] Edward the confessor

F Barlow - 1984 - books.google.com
Frank Barlow's magisterial biography, first published in 1970 and now reissued with new
material, rescues Edward the Confessor from contemporary myth and subsequent bogus …

Apoptosis is increased in a model of diabetes-impaired wound healing in genetically diabetic mice

IA Darby, T Bisucci, TD Hewitson… - The international journal …, 1997 - Elsevier
Impaired wound healing is a common complication of diabetes mellitus. The underlying
pathophysiology of diabetes-impaired healing is poorly understood. In the present study we …

Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease

JP Driver, DV Serreze, YG Chen - Seminars in immunopathology, 2011 - Springer
For almost 30 years, the non-obese diabetic (NOD) mouse has served as the primary model
for dissecting the genetic and pathogenic basis for T-lymphocyte-mediated autoimmune type …

The NOD Idd9 genetic interval influences the pathogenicity of insulitis and contains molecular variants of Cd30, Tnfr2, and Cd137

PA Lyons, WW Hancock, P Denny, CJ Lord, NJ Hill… - Immunity, 2000 - cell.com
Previous analyses of NOD mice have shown that some genes control the development of
both insulitis and diabetes, while other loci influence diabetes without reducing insulitis …

Genetic control of diabetes progression

A Gonzalez, JD Katz, MG Mattei, H Kikutani, C Benoist… - Immunity, 1997 - cell.com
Autoimmune diabetes in both the human and the nonobese diabetic mouse has elaborate
genetics; in the latter case, the disease is influenced by at least 15–20 loci. We anticipated …

Use of nonobese diabetic mice to understand human type 1 diabetes

TC Thayer, SB Wilson… - … and Metabolism Clinics, 2010 - endo.theclinics.com
The use of animal models to study diseases is fundamental to the advancement of the
understanding of basic biologic mechanisms and disease-specific dysfunctions and to the …

Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin-dependent diabetes resistance gene.

DV Serreze, M Prochazka, PC Reifsnyder… - The Journal of …, 1994 - rupress.org
Insulin-dependent diabetes mellitus (IDDM) in NOD/Lt mice represents a complex polygenic
disease. NOR/Lt is a recombinant congenic strain (RCS) in which limited regions of the …