Highlights•Nanofabrication is capable of patterning devices at the same length-scales as
cellular components (ie 10 s of nanometers).•Nanoscale devices can be used to measure …

Spike-frequency adaptation (SFA) is widespread in the CNS, but its function remains
unclear. In neocortical pyramidal neurons, adaptation manifests itself by an increase in the …

Neuronal response properties are typically probed by intracellular measurements of current-
voltage (IV) relationships during application of current or voltage steps. Here we …

Dendritic spines are the primary site of excitatory synaptic input onto neurons, and are
biochemically isolated from the parent dendritic shaft by their thin neck. However, due to the …

Neuronal Noise combines experimental, theoretical and computational results to show how
noise is inherent to neuronal activity, and how noise can be important for neuronal …

Single-neuron models are useful not only for studying the emergent properties of neural
circuits in large-scale simulations, but also for extracting and summarizing in a principled …

Cortical information processing originates from the exchange of action potentials between
many cell types. To capture the essence of these interactions, it is of critical importance to …

Intracellular recordings in vivo remains the best technique to link single-neuron electrical
properties to network function. Yet existing methods are limited in accuracy, throughput, and …

The frequency response properties of neurons are critical for signal transmission and control
of network oscillations. At subthreshold membrane potential, some neurons show resonance …

When the primary visual cortex (V1) is activated by sensory stimulation, what is the temporal
correlation between the synaptic inputs to nearby neurons? This question underlies the …