Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-
modifying factors originally identified as part of an epigenetic cellular memory system that …

The idea that epigenetic determinants such as DNA methylation, histone modifications or
RNA can be passed to the next generation through meiotic products (gametes) is long …

The first major developmental transition in vertebrate embryos is the maternal-to-zygotic
transition (MZT) when maternal mRNAs are degraded and zygotic transcription begins …

Cryopreservation of semen and artificial insemination have an important, positive impact on
cattle production, and product quality. Through the use of cryopreserved semen and artificial …

Background Developmental programming of the embryo is controlled by genetic information
but also dictated by epigenetic information contained in spermatozoa. Lifestyle and …

A father's lifestyle impacts offspring health; yet, the underlying molecular mechanisms
remain elusive. We hypothesized that a diet that changes methyl donor availability will alter …

Heritability has traditionally been thought to be a characteristic feature of the genetic
material of an organism—notably, its DNA. However, it is now clear that inheritance not …

The swiftly changing climate presents a challenge to organismal fitness by creating a
mismatch between the current environment and phenotypes adapted to historic conditions …

Severe or chronic stress and trauma can have a detrimental impact on health. Evidence
suggests that early-life adversity can become biologically embedded and has the potential …

ABSTRACT CTCF is a highly conserved zinc-finger DNA-binding protein that mediates
interactions between distant sequences in the genome. As a consequence, CTCF regulates …