Lipids play crucial roles in regulating aging and longevity. In the past few decades, a series
of genetic pathways have been discovered to regulate lifespan in model organisms …

Caenorhabditis elegans is a small nematode that can be maintained at low cost and
handled using standard in vitro techniques. Unlike toxicity testing using cell cultures, C …

Autophagosome biogenesis is a dynamic membrane event, which is executed by the
sequential function of autophagy-related (ATG) proteins. Upon autophagy induction, a cup …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

The lysosomal–autophagic pathway is activated by starvation and plays an important role in
both cellular clearance and lipid catabolism. However, the transcriptional regulation of this …

Lipid and carbohydrate metabolism are highly conserved processes that affect nearly all
aspects of organismal biology. Caenorhabditis elegans eat bacteria, which consist of lipids …

The C. elegans insulin/IGF-1 signaling (IIS) pathway connects nutrient levels to metabolism,
growth, development, longevity, and behavior. This fundamental pathway is regulated by …

Microalgae are currently emerging as one of the most promising alternative sources for the
next generation of food, feed, cosmetics and renewable energy in the form of biofuel …

Recent research using Drosophila melanogaster has seen a resurgence in studies of
metabolism and physiology. This review focuses on major methods used to conduct this …

Metabolic dysfunction is a primary feature of Werner syndrome (WS), a human premature
aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase …