Keloids constitute an abnormal fibroproliferative wound healing response in which raised
scar tissue grows excessively and invasively beyond the original wound borders. This …

Significance: The aberrant inflammation during wound healing results in pathological
scarring, such as hypertrophic scars and keloids. This adversely affects the quality of life of …

The process of repair of wounded skin involves intricate orchestration not only between the
epidermal and dermal compartments but also between the resident and immigrant cells and …

Mast cells (MCs) are an important immune cell type in the skin and play an active role during
wound healing. MCs produce mediators that can enhance acute inflammation, stimulate re …

Inflammation is a key phase in the cutaneous wound repair process. The activation of
inflammatory cells is critical for preventing infection in contaminated wounds and results in …

Scars are generated in mature skin as a result of the normal repair process, but the
replacement of normal tissue with scar tissue can lead to biomechanical and functional …

The equine distal limb wound healing model, characterized by delayed re-epithelialization
and a fibroproliferative response to wounding similar to that observed in humans, is a …

All species have evolved mechanisms of repair to restore tissue function following injury.
Skin scarring is an inevitable and permanent endpoint for many postnatal organisms except …

Introduction The prevalence of impaired cutaneous wound healing is high and treatment is
difficult and often ineffective, leading to negative social and economic impacts for our …

Significance: Keloid scarring is a disfiguring fibroproliferative disorder that can significantly
impair the quality of life in affected individuals. The mechanisms that initiate keloid scarring …