Abstract RNA polymerase II (Pol II) core promoters are specialized DNA sequences at
transcription start sites of protein-coding and non-coding genes that support the assembly of …

Recent data support the view that epigenetic processes play a role in memory consolidation
and help to transmit acquired memories even across generations in a Lamarckian manner …

By the onset of morphogenesis, Drosophila embryos consist of about 6000 cells that express
distinct gene combinations. Here, we used single-cell sequencing of precisely staged …

Understanding how gene regulatory networks control the progressive restriction of cell fates
is a long-standing challenge. Recent advances in measuring gene expression in single cells …

Developmental enhancers initiate transcription and are fundamental to our understanding of
developmental networks, evolution and disease. Despite their importance, the properties …

The ability to form memories is a prerequisite for an organism's behavioral adaptation to
environmental changes. At the molecular level, the acquisition and maintenance of memory …

Gene expression is regulated by promoters, which initiate transcription, and enhancers,
which control their temporal and spatial activity. However, the discovery that mammalian …

The heart is a highly specialized organ with essential function for the organism throughout
life. The significance of DNA methylation in shaping the phenotype of the heart remains only …

Dynamic protein binding to DNA elements regulates genome function and cell fate. Although
methods for mapping in vivo protein-DNA interactions are becoming crucial for every aspect …

Centromeres are essential chromosomal regions that mediate kinetochore assembly and
spindle attachments during cell division. Despite their functional conservation, centromeres …