Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in
changes at the molecular and cellular levels in T cells. The outside environmental cues are …

T cell activation requires extracellular stimulatory signals that are mainly mediated by T cell
receptor (TCR) complexes. The TCR recognizes antigens on major histocompatibility …

CD4 T cells play critical roles in mediating adaptive immunity to a variety of pathogens. They
are also involved in autoimmunity, asthma, and allergic responses as well as in tumor …

▪ Abstract Src family protein tyrosine kinases are activated following engagement of many
different classes of cellular receptors and participate in signaling pathways that control a …

X-linked agammaglobulinaemia (XLA) is a human immunodeficiency caused by failure of
pre-B cells in the bone marrow to develop into circulating mature B cells. A novel gene has …

Interleukin 7 (IL-7) stimulates the proliferation of B cell progenitors, thymocytes, and mature
T cells through an interaction with a high affinity receptor (IL-7R) belonging to the …

Here, we have studied the activity of a novel protein-tyrosine kinase inhibitor that is selective
for the Src family of tyrosine kinases. We have focused our study on the effects of this …

Epigenetic modifications must underlie lineage-specific differentiation as terminally
differentiated cells express tissue-specific genes, but their DNA sequence is unchanged …

In addition to the antigen receptors, other molecules contribute to cell activation: first, by
functioning as coreceptors (eg, CD4, CD8, CD19/CD21); second, by increasing the avidity of …

Src is the best understood member of a family of 9 tyrosine kinases that regulates cellular
responses to extracellular stimuli. Activated mutants of Src are oncogenic. Using Src as an …