Osteoarthritis (OA) is a progressive degenerative disease resulting in joint deterioration.
Synovial inflammation is present in the OA joint and has been associated with radiographic …

Chronic pain is a substantial personal and societal burden worldwide. Osteoarthritis (OA) is
one of the leading causes of chronic pain and is increasing in prevalence in accordance …

Mast cells are best recognized for their role in allergy and anaphylaxis, but increasing
evidence supports their role in neurogenic inflammation leading to pain and itch. Mast cells …

Osteoarthritis (OA) is the most common joint disease. Currently there are no effective
methods that simultaneously prevent joint degeneration and reduce pain. Although limited …

Osteoarthritis is characterized by articular cartilage breakdown, and emerging evidence
suggests that dysregulated innate immunity is likely involved. Here, we performed …

Osteoarthritis (OA) is the most common form of arthritic disease, leading to disability and
impaired quality of life and no curative treatments exist. Increasing evidence indicates that …

PRG4 is an extracellular matrix protein that maintains homeostasis through its boundary
lubricating and anti-inflammatory properties. Altered expression and function of PRG4 have …

Abstract Purpose of Review Osteoarthritis (OA) is the most common form of arthritis and a
major source of pain and disability worldwide. OA-associated pain is usually refractory to …

Chronic inflammation is implicated in numerous human pathologies. In particular, low-grade
inflammation is currently recognized as an important mechanism of osteoarthritis (OA), at …

In this narrative review, we discuss the emerging role of innate immunity in osteoarthritis
(OA) joint pain. First, we give a brief description of the pain pathway in the context of OA …