Taking diabetes to heart—deregulation of myocardial lipid metabolism in diabetic cardiomyopathy
M Bayeva, KT Sawicki, H Ardehali - Journal of the American Heart …, 2013 - Am Heart Assoc
Heart disease is the leading cause of death in patients with diabetes. 1 Although advances
in medical management and lifestyle interventions have reduced cardiovascular mortality in …
in medical management and lifestyle interventions have reduced cardiovascular mortality in …
Filled carbon nanotubes in biomedical imaging and drug delivery
M Martincic, G Tobias - Expert opinion on drug delivery, 2015 - Taylor & Francis
Introduction: Carbon nanotubes have been advocated as promising candidates in the
biomedical field in the areas of diagnosis and therapy. In terms of drug delivery, the use of …
biomedical field in the areas of diagnosis and therapy. In terms of drug delivery, the use of …
Enhancement of oral bioavailability of poorly water soluble carvedilol by chitosan nanoparticles: Optimization and pharmacokinetic study
A major challenge associated with the oral delivery of anti-hypertensive drugs is their poor
water solubility and low oral bioavailability. Carvedilol (CAR), a potential beta-blocker is …
water solubility and low oral bioavailability. Carvedilol (CAR), a potential beta-blocker is …
From indoles to carbazoles: Tandem Cp* Rh (III)-catalyzed C–H activation/Brønsted acid-catalyzed cyclization reactions
JQ Wu, Z Yang, SS Zhang, CY Jiang, Q Li… - ACS …, 2015 - ACS Publications
A tandem Cp* Rh (III)-catalyzed C–H activation/Brønsted acid-catalyzed intramolecular
cyclization allows a facile synthesis of carbazoles from readily available indoles. The …
cyclization allows a facile synthesis of carbazoles from readily available indoles. The …
Directed evolution of RebH for site‐selective halogenation of large biologically active molecules
We recently characterized the substrate scope of wild‐type RebH and proceeded to evolve
variants of this enzyme with improved stability for biocatalysis. The substrate scopes of both …
variants of this enzyme with improved stability for biocatalysis. The substrate scopes of both …
Late-stage diversification of biologically active molecules via chemoenzymatic C–H functionalization
Engineered variants of rebeccamycin halogenase were used to selectively halogenate a
number of biologically active aromatic compounds. Subsequent Pd-catalyzed cross …
number of biologically active aromatic compounds. Subsequent Pd-catalyzed cross …
Effects of anticancer drugs on the cardiac mitochondrial toxicity and their underlying mechanisms for novel cardiac protective strategies
Mitochondria are organelles that play a pivotal role in the production of energy in cells, and
vital to the maintenance of cellular homeostasis due to the regulation of many biochemical …
vital to the maintenance of cellular homeostasis due to the regulation of many biochemical …
[HTML][HTML] Formulation and characterization of acetazolamide/carvedilol niosomal gel for glaucoma treatment: in vitro, and in vivo study
Acetazolamide (ACZ) is a diuretic used in glaucoma treatment; it has many side effects.
Carvedilol (CAR) is a non-cardioselective beta-blocker used in the treatment of elevated …
Carvedilol (CAR) is a non-cardioselective beta-blocker used in the treatment of elevated …
[HTML][HTML] Clinical trial experience with CA4P anticancer therapy: focus on efficacy, cardiovascular adverse events, and hypertension management
R Grisham, B Ky, KS Tewari, DJ Chaplin… - … oncology research and …, 2018 - Springer
Abstract Combretastatin A4-phosphate (CA4P) is a vascular-disrupting agent (VDA) in
clinical development for the treatment of ovarian and other cancers. In contrast to …
clinical development for the treatment of ovarian and other cancers. In contrast to …
Impact of the mucoadhesive lyophilized wafer loaded with novel carvedilol nano-spanlastics on biochemical markers in the heart of spontaneously hypertensive rat …
NM Sallam, RAB Sanad, MM Ahmed… - Drug Delivery and …, 2021 - Springer
The purpose of this investigation was to encapsulate carvedilol, a model beta-blocker
antihypertensive into nano-spanlastics, followed by incorporation into 1% CMC wafer to …
antihypertensive into nano-spanlastics, followed by incorporation into 1% CMC wafer to …