Heart disease is the leading cause of death in patients with diabetes. 1 Although advances
in medical management and lifestyle interventions have reduced cardiovascular mortality in …

Introduction: Carbon nanotubes have been advocated as promising candidates in the
biomedical field in the areas of diagnosis and therapy. In terms of drug delivery, the use of …

A major challenge associated with the oral delivery of anti-hypertensive drugs is their poor
water solubility and low oral bioavailability. Carvedilol (CAR), a potential beta-blocker is …

A tandem Cp* Rh (III)-catalyzed C–H activation/Brønsted acid-catalyzed intramolecular
cyclization allows a facile synthesis of carbazoles from readily available indoles. The …

We recently characterized the substrate scope of wild‐type RebH and proceeded to evolve
variants of this enzyme with improved stability for biocatalysis. The substrate scopes of both …

Engineered variants of rebeccamycin halogenase were used to selectively halogenate a
number of biologically active aromatic compounds. Subsequent Pd-catalyzed cross …

Mitochondria are organelles that play a pivotal role in the production of energy in cells, and
vital to the maintenance of cellular homeostasis due to the regulation of many biochemical …

Acetazolamide (ACZ) is a diuretic used in glaucoma treatment; it has many side effects.
Carvedilol (CAR) is a non-cardioselective beta-blocker used in the treatment of elevated …

Abstract Combretastatin A4-phosphate (CA4P) is a vascular-disrupting agent (VDA) in
clinical development for the treatment of ovarian and other cancers. In contrast to …

The purpose of this investigation was to encapsulate carvedilol, a model beta-blocker
antihypertensive into nano-spanlastics, followed by incorporation into 1% CMC wafer to …