It is estimated that approximately one billion people are at risk of infection with obligate
intracellular bacteria, but little is known about the underlying mechanisms that govern their …

The genus Rickettsia (Alphaproteobacteria, Rickettsiales, Rickettsiaceae) is comprised of
obligate intracellular parasites, with virulent species of interest both as causes of emerging …

Ticks are of medical importance owing to their ability to transmit pathogens to humans and
animals. The Rocky Mountain wood tick, Dermacentor andersoni, is a vector of a number of …

We obtained a rickettsial isolate from the ovaries of the blacklegged tick, Ixodes scapularis.
The isolate (ISO7T) was grown in the Ixodes ricinus embryonic cell line IRE11. We …

The immune deficiency (IMD) pathway directs host defense in arthropods upon bacterial
infection. In Pancrustacea, peptidoglycan recognition proteins sense microbial moieties and …

Hematophagous arthropods are responsible for the transmission of a variety of pathogens
that cause disease in humans and animals. Ticks of the Ixodes ricinus complex are vectors …

The ability to genetically manipulate a pathogen is fundamental to discovering factors
governing host–pathogen interactions at the molecular level and is critical for devising …

A reduction in the use of animals in infectious disease research is desirable for animal
welfare as well as for simplification and standardization of experiments. An artificial silicone …

A diverse spectrum of intracellular bacterial pathogens that inhabit the cytosol have evolved
the ability to polymerize actin on their surface to power intracellular actin-based motility …

Wolbachia are intracellular endosymbionts of several invertebrate taxa, including insects
and nematodes. Although Wolbachia DNA has been detected in ticks, its presence is …