The genetic basis of obesity and related metabolic diseases in humans and companion animals

N Wallis, E Raffan - Genes, 2020 - mdpi.com
Obesity is one of the most prevalent health conditions in humans and companion animals
globally. It is associated with premature mortality, metabolic dysfunction, and multiple health …

Animal models for the study of the relationships between diet and obesity: a focus on dietary protein and estrogen deficiency

T Chalvon-Demersay, F Blachier, D Tomé… - Frontiers in …, 2017 - frontiersin.org
Obesity is an increasing major public health concern asking for dietary strategies to limit
weight gain and associated comorbidities. In this review, we present animal models …

Frequency, breed predisposition and demographic risk factors for overweight status in dogs in the UK

C Pegram, E Raffan, E White… - Journal of Small …, 2021 - Wiley Online Library
Objectives To evaluate the prevalence and risk factors for overweight status in dogs under
primary veterinary care in the UK. Materials and Methods A retrospective study design was …

Analysis of large versus small dogs reveals three genes on the canine X chromosome associated with body weight, muscling and back fat thickness

J Plassais, M Rimbault, FJ Williams, BW Davis… - PLoS …, 2017 - journals.plos.org
Domestic dog breeds display significant diversity in both body mass and skeletal size,
resulting from intensive selective pressure during the formation and maintenance of modern …

Genetic marker discovery in complex traits: a field example on fat content and composition in pigs

RN Pena, R Ros-Freixedes, M Tor, J Estany - International Journal of …, 2016 - mdpi.com
Among the large number of attributes that define pork quality, fat content and composition
have attracted the attention of breeders in the recent years due to their interaction with …

Hypercaloric diet-induced obesity and obesity-related metabolic disorders in experimental models

N Pinheiro-Castro, LBAR Silva, GM Novaes… - Reviews on Biomarker …, 2019 - Springer
Overnutrition and obesity have developed into a major public health problem across
different parts of the world. Epidemiological studies have shown that excessive intake of …

The importance of the nuclear positioning of the PPARG gene for its expression during porcine in vitro adipogenesis

J Stachecka, J Nowacka-Woszuk, PA Kolodziejski… - Chromosome …, 2019 - Springer
Proper expression of the PPARG gene, which encodes a key transcription factor of
adipogenesis, is indispensable in the formation of mature adipocytes. The positioning of a …

Confirmation that a deletion in the POMC gene is associated with body weight of Labrador Retriever dogs

M Mankowska, P Krzeminska, M Graczyk… - Research in veterinary …, 2017 - Elsevier
A 14-bp deletion present in the proopiomelanocortin (POMC) gene of Labrador and Flat
Coat Retrievers (FCR), but absent in POMC of other breeds, disrupts the β-MSH and β …

Identification of Signatures of Positive Selection That Have Shaped the Genomic Landscape of South African Pig Populations

NL Hlongwane, EF Dzomba, K Hadebe… - Animals, 2024 - mdpi.com
Simple Summary Pigs are important in agriculture as they produce animal-based protein for
human consumption. The analysis of selection signatures has implications for the …

Expression of key genes involved in DNA methylation during in vitro differentiation of porcine mesenchymal stem cells (MSCs) into adipocytes

J Stachecka, W Lemanska, M Noak… - … and Biophysical Research …, 2020 - Elsevier
The normal course of DNA methylation depends on the correct functioning of the DNA
methylation machinery, which include DNA methyltransferase enzymes (DNMTs) and methyl …