DNA methylation-based predictors of health: applications and statistical considerations
DNA methylation data have become a valuable source of information for biomarker
development, because, unlike static genetic risk estimates, DNA methylation varies …
development, because, unlike static genetic risk estimates, DNA methylation varies …
Exploring the evidence for epigenetic regulation of environmental influences on child health across generations
CV Breton, R Landon, LG Kahn, MB Enlow… - Communications …, 2021 - nature.com
Environmental exposures, psychosocial stressors and nutrition are all potentially important
influences that may impact health outcomes directly or via interactions with the genome or …
influences that may impact health outcomes directly or via interactions with the genome or …
The social origins of obesity within and across generations
We propose a model for obesity development that traces a considerable part of its origins to
the social domain (mainly different forms of prolonged social adversity), both within and …
the social domain (mainly different forms of prolonged social adversity), both within and …
Overweight and obesity in pregnancy: their impact on epigenetics
C Reichetzeder - European journal of clinical nutrition, 2021 - nature.com
Over the last few decades, the prevalence of obesity has risen to epidemic proportions
worldwide. Consequently, the number of obesity in pregnancy has risen drastically …
worldwide. Consequently, the number of obesity in pregnancy has risen drastically …
Epigenetic programming and fetal metabolic programming
Z Zhu, F Cao, X Li - Frontiers in endocrinology, 2019 - frontiersin.org
Fetal metabolic programming caused by the adverse intrauterine environment can induce
metabolic syndrome in adult offspring. Adverse intrauterine environment introduces fetal …
metabolic syndrome in adult offspring. Adverse intrauterine environment introduces fetal …
The LifeCycle Project-EU Child Cohort Network: a federated analysis infrastructure and harmonized data of more than 250,000 children and parents
VWV Jaddoe, JF Felix, AMN Andersen… - European journal of …, 2020 - Springer
Early life is an important window of opportunity to improve health across the full lifecycle. An
accumulating body of evidence suggests that exposure to adverse stressors during early life …
accumulating body of evidence suggests that exposure to adverse stressors during early life …
[HTML][HTML] Epigenome-wide meta-analysis of DNA methylation and childhood asthma
Background Epigenetic mechanisms, including methylation, can contribute to childhood
asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease …
asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease …
Cell-type deconvolution from DNA methylation: a review of recent applications
Recent advances in cell-type deconvolution approaches are adding to our understanding of
the biology underlying disease development and progression. DNA methylation (DNAm) …
the biology underlying disease development and progression. DNA methylation (DNAm) …
Maternal dysglycaemia, changes in the infant's epigenome modified with a diet and physical activity intervention in pregnancy: Secondary analysis of a randomised …
Background Higher maternal plasma glucose (PG) concentrations, even below gestational
diabetes mellitus (GDM) thresholds, are associated with adverse offspring outcomes, with …
diabetes mellitus (GDM) thresholds, are associated with adverse offspring outcomes, with …