Most of the anti-inflammatory drugs in clinical practice are becoming outdated owing to their
potential side and adverse effects. These are found to be highly unsafe for long term use …

NSAIDs are the most famous anti-inflammatory drugs and are mainly classified into two
groups, the non-selective NSAIDs that inhibit both COX-1 and COX-2 enzymes with side …

Benzimidazoles are a class of heterocyclic, aromatic compounds which share a fundamental
structural characteristic of six-membered benzene fused to fivemembered imidazole moiety …

Aim: Over the last few decades, therapeutic needs have led to a search for safer COX-2
inhibitors with potential anti-inflammatory and analgesic activity. Materials & methods: A new …

Benzimidazole is a privileged drug design and discovery scaffold with various
pharmacological activities, including antimicrobial, anticancer, antitubercular, anti …

Mannich bases are beta-amino ketone-carrying compounds that are the end products of the
Mannich reaction. The Mannich reaction is essential in the synthesis of nitrogen-containing …

Designed, synthesized a sequence of novel benzimidazol‐1‐yl‐1‐phenylpropanone hybrids
and assessed for in vitro antimicrobial potential counter to several bacterial strains …

Anti-inflammatory drugs are a ubiquitous class of analgesics used by millions of people
worldwide. Owing to the widespread and prolonged use of Anti-inflammatory drugs, chronic …

A series of newfangled benzimidazole-1-yl-1-(4-chlorophenyl) propan-1-one hybrids were
designed and synthesized in good to excellent yield via classical Mannich base reaction …

Numerous physiologically active combinations containing nitrogen, sulphur, and oxygen
heteroatoms which intrigued the interest of chemists throughout centuries, owing to their …