Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling
through macromolecular breakdown to coordinate programmes for growth, repair and stress …

Lysosomes are degradation centers and signaling hubs in cells and play important roles in
cellular homeostasis, development, and aging. Changes in lysosome function are essential …

Autophagy is a major intracellular degradation system that derives its degradative abilities
from the lysosome. The most well-studied form of autophagy is macroautophagy, which …

Cathepsins are the most abundant lysosomal proteases that are mainly found in acidic
endo/lysosomal compartments where they play a vital role in intracellular protein …

Lysosomes are membrane‐enclosed organelles that mediate the intracellular degradation
of macromolecules. They play an essential role in calcium regulation and have emerged as …

Newly endocytosed integral cell surface proteins are typically either directed for degradation
or subjected to recycling back to the plasma membrane. The sorting of integral cell surface …

Mammalian cells can acquire exogenous amino acids through endocytosis and lysosomal
catabolism of extracellular proteins. In amino acid-replete environments, nutritional …

INTRODUCTION Lysosomes are degradative organelles that break down diverse materials
delivered from inside and outside the cell by specialized vesicles called endosomes …

Lysosomes are single membrane-bound organelles containing acid hydrolases responsible
for the degradation of cellular cargo and maintenance of cellular homeostasis. Lysosomes …

Abnormalities of the endosomal–lysosomal network (ELN) are a signature feature of
Alzheimer's disease (AD). These include the earliest known cytopathology that is specific to …