Autoantibodies in neurological disease

H Prüss - Nature reviews immunology, 2021 - nature.com
The realization that autoantibodies can contribute to dysfunction of the brain has brought
about a paradigm shift in neurological diseases over the past decade, offering up important …

Antibody-mediated encephalitis

J Dalmau, F Graus - New England Journal of Medicine, 2018 - Mass Medical Soc
Antibody-Mediated Encephalitis The category of autoimmune encephalitides constitutes
disorders with relatively distinct characteristics such as psychosis, seizures, abnormal …

Updated diagnostic criteria for paraneoplastic neurologic syndromes

F Graus, A Vogrig, S Muñiz-Castrillo… - Neurology …, 2021 - AAN Enterprises
Objective The contemporary diagnosis of paraneoplastic neurologic syndromes (PNSs)
requires an increasing understanding of their clinical, immunologic, and oncologic …

A clinical approach to diagnosis of autoimmune encephalitis

F Graus, MJ Titulaer, R Balu, S Benseler… - The lancet …, 2016 - thelancet.com
Encephalitis is a severe inflammatory disorder of the brain with many possible causes and a
complex differential diagnosis. Advances in autoimmune encephalitis research in the past …

Autoimmune encephalitis: clinical spectrum and management

CE Uy, S Binks, SR Irani - Practical neurology, 2021 - pn.bmj.com
Autoimmune encephalitis defines brain inflammation caused by a misdirected immune
response against self-antigens expressed in the central nervous system. It comprises a …

Clinical approach to the diagnosis of autoimmune encephalitis in the pediatric patient

T Cellucci, H Van Mater, F Graus, E Muscal… - Neurology …, 2020 - AAN Enterprises
Objective Autoimmune encephalitis (AE) is an important and treatable cause of acute
encephalitis. Diagnosis of AE in a developing child is challenging because of overlap in …

Autoantibodies to synaptic receptors and neuronal cell surface proteins in autoimmune diseases of the central nervous system

J Dalmau, C Geis, F Graus - Physiological reviews, 2017 - journals.physiology.org
Investigations in the last 10 years have revealed a new category of neurological diseases
mediated by antibodies against cell surface and synaptic proteins. There are currently 16 …

Complement in neurological disorders and emerging complement-targeted therapeutics

MC Dalakas, H Alexopoulos, PJ Spaeth - Nature Reviews Neurology, 2020 - nature.com
The complement system consists of a network of plasma and membrane proteins that
modulate tissue homeostasis and contribute to immune surveillance by interacting with the …

Autoimmune encephalopathies

F Leypoldt, T Armangue… - Annals of the New York …, 2015 - Wiley Online Library
Over the past 10 years, the continual discovery of novel forms of encephalitis associated
with antibodies to cell‐surface or synaptic proteins has changed the paradigms for …

GAD antibodies in neurological disorders—insights and challenges

F Graus, A Saiz, J Dalmau - Nature Reviews Neurology, 2020 - nature.com
Antibodies to glutamic acid decarboxylase (GAD) have been associated with several
neurological syndromes, including stiff-person syndrome, cerebellar ataxia and epilepsy …