Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

Apoptosis is an evolutionary conserved homeostatic process involved in distinct
physiological processes including organ and tissue morphogenesis, development and …

Intracellular pH (pH i) has an important role in the maintenance of normal cell function, and
hence this parameter has to be tightly controlled within a narrow range, largely through the …

Air pollution is the leading cause of lung cancer after tobacco smoking, contributing to 20%
of all lung cancer deaths. Increased risk associated with living near trafficked roads …

Bisphenol A (BPA) is an endocrine-disrupting chemical that leaches from polycarbonate
plastics that consequently leads to low-dose human exposure. In addition to its known …

We have previously shown that cisplatin triggers an early acid sphingomyelinase (aSMase)-
dependent ceramide generation concomitantly with an increase in membrane fluidity and …

Environmental and dietary carcinogens such as polycyclic aromatic hydrocarbons (PAHs)
have been intensively studied for decades. Although the genotoxicity of these compounds is …

Most current anticancer therapies induce tumor cell death through apoptosis where its
specific involved pathways are poorly understood. For example, for many DNA-damaging …

Cancer cells display alterations in many cellular processes. One core hallmark of cancer is
the Warburg effect which is a glycolytic reprogramming that allows cells to survive and …

Nitrated-polycyclic aromatic hydrocarbons (nitro-PAHs) and diesel exhaust particle extracts
(DEPE) induced apoptosis in Hepa1c1c7 cells with the following potency: 1, 3-dinitropyrene …