Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …

Aging is a natural process, which plays a critical role in the pathogenesis of a variety of
diseases, ie, aging-related diseases, such as diabetes, osteoarthritis, Alzheimer disease …

Metformin can improve patients' hyperglycemia through significant suppression of hepatic
glucose production. However, up to 300 times higher concentrations of metformin …

Metformin is the most commonly prescribed drug for type 2 diabetes mellitus. In recent years,
in addition to glucose lowering, several studies have presented evidence suggesting some …

With an increasing global burden of coronary artery disease (CAD), early detection and
timely management of risk factors are crucial to reduce morbidity and mortality in such …

Purpose of review Insulin resistance (IR) is recognized to play an important role in the
pathogenesis of dyslipidemia. This review summarizes the complex interplay between IR …

Patients with diabetes type 2 have an increased risk for cardiovascular disease and
commonly use combination therapy consisting of the anti-diabetic drug metformin and a …

Parkinson's disease (PD) is a common neurodegenerative disease developed due to the
degeneration of dopaminergic neurons in the substantia nigra. There is no single effective …

Metformin (dimethyl‐biguanide) can claim its origins in the use of Galega officinalis as a
plant treatment for symptoms ascribed to diabetes. Since the first clinical use of metformin as …

Metformin has been the first-line drug treatment for hyperglycemia and insulin resistance for
over 50 years. However, the molecular basis of its therapeutic role remained incompletely …