Translational control of stem cell function
JA Saba, K Liakath-Ali, R Green, FM Watt - Nature reviews Molecular …, 2021 - nature.com
Stem cells are characterized by their ability to self-renew and differentiate into many different
cell types. Research has focused primarily on how these processes are regulated at a …
cell types. Research has focused primarily on how these processes are regulated at a …
Connecting mitochondria, metabolism, and stem cell fate
As sites of cellular respiration and energy production, mitochondria play a central role in cell
metabolism. Cell differentiation is associated with an increase in mitochondrial content and …
metabolism. Cell differentiation is associated with an increase in mitochondrial content and …
Autophagy and stem cells: self-eating for self-renewal
NC Chang - Frontiers in Cell and Developmental Biology, 2020 - frontiersin.org
Autophagy is a fundamental cell survival mechanism that allows cells to adapt to metabolic
stress through the degradation and recycling of intracellular components to generate …
stress through the degradation and recycling of intracellular components to generate …
Autophagy in stem cells: repair, remodelling and metabolic reprogramming
Autophagy is a catabolic pathway by which cellular components are delivered to the
lysosome for degradation and recycling. Autophagy serves as a crucial intracellular quality …
lysosome for degradation and recycling. Autophagy serves as a crucial intracellular quality …
Regenerative proliferation of differentiated cells by mTORC 1‐dependent paligenosis
In 1900, Adami speculated that a sequence of context‐independent energetic and structural
changes governed the reversion of differentiated cells to a proliferative, regenerative state …
changes governed the reversion of differentiated cells to a proliferative, regenerative state …
Pluripotent stem cell energy metabolism: an update
T Teslaa, MA Teitell - The EMBO journal, 2015 - embopress.org
Recent studies link changes in energy metabolism with the fate of pluripotent stem cells
(PSC s). Safe use of PSC derivatives in regenerative medicine requires an enhanced …
(PSC s). Safe use of PSC derivatives in regenerative medicine requires an enhanced …
A continuous molecular roadmap to iPSC reprogramming through progression analysis of single-cell mass cytometry
To analyze cellular reprogramming at the single-cell level, mass cytometry was used to
simultaneously measure markers of pluripotency, differentiation, cell-cycle status, and …
simultaneously measure markers of pluripotency, differentiation, cell-cycle status, and …
Transient activation of autophagy via Sox2-mediated suppression of mTOR is an important early step in reprogramming to pluripotency
Autophagy is an essential cellular mechanism that degrades cytoplasmic proteins and
organelles to recycle their components. Here we show that autophagy is required for …
organelles to recycle their components. Here we show that autophagy is required for …
Ribosome and translational control in stem cells
M Gabut, F Bourdelais, S Durand - Cells, 2020 - mdpi.com
Embryonic stem cells (ESCs) and adult stem cells (ASCs) possess the remarkable capacity
to self-renew while remaining poised to differentiate into multiple progenies in the context of …
to self-renew while remaining poised to differentiate into multiple progenies in the context of …
Energy metabolism and energy-sensing pathways in mammalian embryonic and adult stem cell fate
Metabolism is influenced by age, food intake, and conditions such as diabetes and obesity.
How do physiological or pathological metabolic changes influence stem cells, which are …
How do physiological or pathological metabolic changes influence stem cells, which are …