Leukoplakia and erythroplakia are two entities under the moniker of “oral potentially
malignant disorders” that are highly associated with the presence of oral epithelial dysplasia …

Head and neck squamous cell carcinomas (HNSCC) arising from the oral cavity, pharynx,
and larynx constitute the 6 th most common human cancer. Human papillomavirus (HPV) …

Hypermethylation of CpG islands in the promoter regions is an important mechanism to
silence the expression of many important genes in cancer. The hypermethylation status is …

Purpose Human papillomavirus (HPV) DNA tumors actively integrating the E6 and E7
oncogenes have a distinct biologic behavior resulting in a more favorable prognosis. To …

Purpose: Squamous cell carcinoma of the oral cavity is one of the most common human
neoplasms, and prevention of these carcinomas requires a better understanding of the …

Head and neck squamous-cell carcinoma (HNSCC) is the sixth most common cancer
worldwide and, disappointingly, survival rates are not improving. Moreover, HNSCC has a …

Simple Summary Oral potentially malignant disorders (OPMDs) include a group of oral
mucosal diseases with different morphological characteristics that are able to progress to …

Background: Transcriptionally active high-risk human papilloma viruses (HPVs), particularly
HPV type 16 (HPV16), are found in a subset of head and neck squamous-cell carcinomas …

A major barrier to oral cancer prevention has been the lack of validated risk predictors for
oral premalignant lesions (OPL). In 2000, we proposed a loss of heterozygosity (LOH) risk …

Identification and management of potentially premalignant oral epithelial lesions (PPOELs)
at highest risk of malignant transformation holds great promise for successful secondary …