On the perturbation nature of allostery: sites, mutations, and signal modulation
E Guarnera, IN Berezovsky - Current opinion in structural biology, 2019 - Elsevier
Regardless of the diversity of systems, allosteic signalling is found to be always caused by
perturbations. This recurring trait of allostery serves as a foundation for developing different …
perturbations. This recurring trait of allostery serves as a foundation for developing different …
Heteromeric solute carriers: function, structure, pathology and pharmacology
SJ Fairweather, N Shah, S Brӧer - Protein Reviews: Volume 21, 2021 - Springer
Solute carriers form one of three major superfamilies of membrane transporters in humans,
and include uniporters, exchangers and symporters. Following several decades of …
and include uniporters, exchangers and symporters. Following several decades of …
The allosteric mechanism leading to an open-groove lipid conductive state of the TMEM16F scramblase
TMEM16F is a Ca2+-activated phospholipid scramblase in the TMEM16 family of membrane
proteins. Unlike other TMEM16s exhibiting a membrane-exposed hydrophilic groove that …
proteins. Unlike other TMEM16s exhibiting a membrane-exposed hydrophilic groove that …
X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release
Neurotransmitter: sodium symporters (NSS) are conserved from bacteria to man and serve
as targets for drugs, including antidepressants and psychostimulants. Here we report the X …
as targets for drugs, including antidepressants and psychostimulants. Here we report the X …
Exploring the allosteric territory of protein function
While the pervasiveness of allostery in proteins is commonly accepted, we further show the
generic nature of allosteric mechanisms by analyzing here transmembrane ion-channel …
generic nature of allosteric mechanisms by analyzing here transmembrane ion-channel …
Investigating the mechanism of sodium binding to SERT using direct simulations
D Szöllősi, T Stockner - Frontiers in Cellular Neuroscience, 2021 - frontiersin.org
The serotonin transporter (SERT) terminates neurotransmission by transporting serotonin
from the synapse into the pre-synaptic nerve terminal. Altered SERT function leads to …
from the synapse into the pre-synaptic nerve terminal. Altered SERT function leads to …
Computational dissection of membrane transport at a microscopic level
Membrane transporters are key gatekeeper proteins at cellular membranes that closely
control the traffic of materials. Their function relies on structural rearrangements of varying …
control the traffic of materials. Their function relies on structural rearrangements of varying …
How structural elements evolving from bacterial to human SLC6 transporters enabled new functional properties
AM Razavi, G Khelashvili, H Weinstein - BMC biology, 2018 - Springer
Background Much of the structure-based mechanistic understandings of the function of
SLC6A neurotransmitter transporters emerged from the study of their bacterial LeuT-fold …
SLC6A neurotransmitter transporters emerged from the study of their bacterial LeuT-fold …
A structural model of the human serotonin transporter in an outward-occluded state
E Hellsberg, GF Ecker, A Stary-Weinzinger… - PLoS One, 2019 - journals.plos.org
The human serotonin transporter hSERT facilitates the reuptake of its endogenous substrate
serotonin from the synaptic cleft into presynaptic neurons after signaling. Reuptake …
serotonin from the synaptic cleft into presynaptic neurons after signaling. Reuptake …
The allosteric mechanism of substrate-specific transport in SLC6 is mediated by a volumetric sensor
Neurotransmitter: sodium symporters (NSSs) in the SLC6 family terminate
neurotransmission by coupling the thermodynamically favorable transport of ions to the …
neurotransmission by coupling the thermodynamically favorable transport of ions to the …