Rab GTPases comprise a large family of conserved GTPases that are critical regulators of
the secretory and endocytic pathways. The human genome encodes~ 65 Rabs that localize …

Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting millions of
people worldwide. Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are …

Mutations enhancing the kinase activity of leucine-rich repeat kinase-2 (LRRK2) cause
Parkinson's disease (PD) and therapies that reduce LRRK2 kinase activity are being tested …

Activating mutations in the leucine-rich repeat kinase 2 (LRRK2) cause Parkinson's disease.
LRRK2 phosphorylates a subset of Rab GTPases, particularly Rab10 and Rab8A, and we …

Activating mutations in the leucine-rich repeat kinase 2 (LRRK2) cause Parkinson's disease,
and previously we showed that activated LRRK2 phosphorylates a subset of Rab GTPases …

We demonstrate that the Parkinson's VPS35 [D620N] mutation alters the expression of~ 220
lysosomal proteins and stimulates recruitment and phosphorylation of Rab proteins at the …

Mutations in the human leucine rich repeat protein kinase-2 (LRRK2) create risk factors for
Parkinson's disease, and pathological functions of LRRK2 are often correlated with aberrant …

Rab proteins are small GTPases that regulate a myriad of intracellular membrane trafficking
events. Rab29 is one of the Rab proteins phosphorylated by leucine-rich repeat kinase 2 …

Mutations in LRRK2, a large multi-domain protein kinase, create risk factors for Parkinson's
Disease (PD). LRRK2 has seven well-folded domains that include three N-terminal scaffold …

Pathogenic mutations in the leucine-rich repeat kinase 2 (LRRK2) gene hyperactivate
LRRK2 kinase activity and lead to the development of Parkinson's disease (PD). Membrane …